Min M Hu

6974805, Dec 13, 2005

Aug 1, 2003

10/632599

Min Hu - Fremont CA, US

A61K031/726
A61K031/715
A61K031/738

514 54, 536 551, 536 53

The present invention provides stable glycosaminoglycan (GSG) structures and methods of use of such GAG structures. These structures comprise a core of free GAG, a coating of crosslinked GAG surrounding the core, and a layer of a positively charged moiety surrounding the crosslinked GAG layer. These GAG structures provide improved stability, both in in vivo and external use. Furthermore, resurfacing of the structures provides improved cell adhesion and thus improved delivery of the GAG into living cells and tissues.

8243270, Aug 14, 2012

Jan 29, 2010

12/697156

Huei Pei Kuo - Cupertino CA, US
Michael J. Stuke - Palo Alto CA, US
Min Hu - Sunnyvale CA, US
Fung Suong Ou - Palo Alto CA, US
Shih-Yuan (SY) Wang - Palo Alto CA, US
Alexandre M. Bratkovski - Mountain View CA, US
Wei Wu - Palo Alto CA, US
Zhiyong Li - Redwood City CA, US

Hewlett-Packard Development Company, L.P. - Houston TX

G01J 3/44

356301

A vibrating tip surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a nano-needle configured to vibrate. The apparatus includes the nano-needle with a substantially sharp tip at a free end opposite an end attached to a substrate. The tip is configured to adsorb an analyte. The apparatus further includes a vibration source configured to provide an alternating current (AC) electric field that induces a vibration of the free end and the tip of the nano-needle. Vibration of the nano-needle under the influence of the AC electric field facilitates detection of a Raman scattering signal from the analyte adsorbed on the nano-needle tip. The system further includes a synchronous detector configured to be gated cooperatively with the vibration of the nano-needle. The method includes inducing the vibration, illuminating the vibrating tip to produce a Raman signal, and detecting the Raman signal using the detector.

8269963, Sep 18, 2012

Apr 30, 2010

12/771779

Fung Suong Ou - Palo Alto CA, US
Min Hu - Sunnyvale CA, US
Wei Wu - Palo Alto CA, US
Zhiyong Li - Redwood City CA, US
R Stanley Williams - Portola Valley CA, US

Hewlett-Packard Development Company, L.P. - Houston TX

G01J 3/44

356301

A tunable apparatus for performing Surface Enhanced Raman Spectroscopy (SERS) includes a deformable layer and a plurality of SERS-active nanoparticles disposed at one or more locations on the deformable layer, wherein the one or more locations are configured to be illuminated with light of a pump wavelength to cause Raman excitation light to interact with the nanoparticles and produce enhanced Raman scattered light from molecules located in close proximity to the nanoparticles. In addition, a morphology of the deformable layer is configured to be controllably varied to modify an intensity of the Raman scattered light produced from the molecules.

8279437, Oct 2, 2012

Jul 14, 2010

12/836097

Min Hu - Sunnyvale CA, US
Alexandre M. Bratkovski - Mountain View CA, US
Huel Pei Kuo - Cupertino CA, US
Jingjing Li - Palo Alto CA, US
Zhiyong Li - Redwood City CA, US
Fung Suong Ou - Palo Alto CA, US
Michael Josef Stuke - Palo Alto CA, US
Michael Renne Ty Tan - Menlo Park CA, US
Shih-Yuan Wang - Palo Alto CA, US
Wei Wu - Palo Alto CA, US

Hewlett-Packard Development Company, L.P. - Houston TX

G01J 3/44

356301

An apparatus for detecting at least one species using Raman light detection includes at least one laser source for illuminating a sample containing the at least one species. The apparatus also includes a modulating element for modulating a spatial relationship between the sample and the light beams to cause relative positions of the sample and the light beams to be oscillated, in which Raman light at differing intensity levels are configured to be emitted from the at least one species based upon the different wavelengths of the light beams illuminating the sample. The apparatus also includes a Raman light detector and a post-signal processing unit configured to detect the at least one species.

8314932, Nov 20, 2012

Apr 30, 2010

12/771440

Fung Suong Ou - Mountain View CA, US
Zhiyong Li - Redwood City CA, US
Min Hu - Sunnyvale CA, US
Wei Wu - Palo Alto CA, US

Hewlett-Packard Development Company, L.P. - Houston TX

G01J 3/44

356301

A surface-enhanced Raman spectroscopy device includes a substrate, and an ultraviolet cured resist disposed on the substrate. The ultraviolet cured resist has a pattern of cone-shaped protrusions, where each cone-shaped protrusion has a tip with a radius of curvature equal to or less than 10 nm. The ultraviolet cured resist is formed of a predetermined ratio of a photoinitiator, a cross-linking agent, and a siloxane based backbone chain. A Raman signal-enhancing material is disposed on each of the cone-shaped protrusions.

8319963, Nov 27, 2012

Apr 30, 2010

12/772063

Min Hu - Sunnyvale CA, US
Wei Wu - Palo Alto CA, US
Fung Suong Ou - Palo Alto CA, US
Zhen Peng - PFoster City CA, US
Zhiyong Li - Redwood City CA, US
R. Stanley Williams - Portola Valley CA, US

Hewlett-Packard Development Company, L.P. - Houston TX

G01J 3/44

356301

A compact sensor system comprising: an analysis cell configured for photon-matter interaction, where photons are received from a light source; and an integrated-optical spectral analyzer configured for identifying a set of frequencies, the integrated-optical spectral analyzer comprising: a waveguide coupled with the analysis cell, the waveguide configured for propagating a set of frequencies through the waveguide; one or more ring resonators coupled with the waveguide, the one or more ring resonators comprising a predetermined bandwidth and configured for capturing the set of frequencies corresponding to frequencies within the predetermined bandwidth; and one or more frequency detectors coupled with the one or more tunable ring resonators, the one or more frequency detectors configured for generating electrical signals that identify each of the set of frequencies.

8358407, Jan 22, 2013

Apr 30, 2010

12/771753

Min Hu - Sunnyvale CA, US
Wei Wu - Palo Alto CA, US
Fung Suong Ou - Palo Alto CA, US
Zhiyong Li - Redwood City CA, US
R. Stanley Williams - Portola Valley CA, US

Hewlett-Packard Development Company, L.P. - Houston TX

G01J 3/40

356301

An integrated device for enhancing signals in Surface Enhanced Raman Spectroscopy (SERS). The integrated device comprising an array of nanostructures comprising a material, wherein the material is configured to allow light to pass through. The integrated device also comprising SERS active nanoparticles disposed on at least portion of the array of nanostructures and a mirror integrated below a base of the array of nanostructures. The mirror is configured to reflect light passing through the material into the array of nanostructures.

8358408, Jan 22, 2013

Apr 30, 2010

12/771824

Wei Wu - Palo Alto CA, US
Min Hu - Sunnyvale CA, US
Fung Suong Ou - Palo Alto CA, US
Zhiyong Li - Redwood City CA, US

Hewlett-Packard Development Company, L.P. - Houston TX

G01J 3/44

356301

An apparatus for performing Surface Enhanced Raman Spectroscopy (SERS) includes a reflective layer positioned above the substrate, a plurality of tapered nanowires disposed above the reflective layer, each of the plurality of tapered nanowires having a tapered end directed away from the reflective layer.