Inventors:
H. Thomas Lee - New York NY, US
Mihwa Kim - Merrick NY, US
Assignee:
The Trustees of Columbia University in the City of New York - New York NY
International Classification:
A61K 31/133
A61K 31/661
A61K 48/00
C12Q 1/02
G01N 30/02
C12Q 1/42
A61P 1/16
A61P 13/12
A61P 9/10
A61K 31/137
C12N 5/00
US Classification:
514 44 R, 514653, 514669, 514114, 435 29, 435375, 435 21, 73 6152
Abstract:
The invention relates to the treatment and diagnosis of organ dysfunction caused by ischemia reperfusion injury. In particular, the invention relates to sphinganine-1-phosphate, a sphingolipid metabolite, and its use in the diagnosing, preventing, and/or treating ischemia reperfusion-associated disorders, including, without limitation, disorders of the kidney, liver, lung, brain, and heart.