Li Yi Chen

6445734, Sep 3, 2002

Jun 30, 1999

09/343873

Li Chen - Irvine CA
Farhad Aminian - Irvine CA
Keith T. Chu - Laguna Niguel CA

Conexant Systems, Inc. - Newport Beach CA

H03H 730

375231, 375232, 375350, 708305, 708323

Equalizer training is validated by techniques to detect false training. The validation techniques involve checking the unique time domain energy shaping of a plurality of taps of a trained equalizer of a modem for good training. The energy measure for each equalizer tap of the plurality of taps is approximated by summing the magnitude of a real component and a magnitude of an imaginary component of an equalizer coefficient corresponding to the equalizer tap. A tap with a highest approximate energy (i. e. , the main tap) is then determined. Next, the main tap energy is compared to a main tap threshold and a predetermined guarding threshold. The plurality of taps are arranged in a time index ordered sequence. In determining the main tap threshold, a first energy sum of a beginning set of taps in the sequence is compared with a second energy sum of a last set of taps in the sequence. The lesser tap energy sum between the first energy sum and the second energy sum is the main tap threshold.

6455550, Sep 24, 2002

Aug 21, 1998

09/138353

Li Chen - Westfield NJ
Robert William Guthrie - Saddle Brook NJ
Jefferson Wright Tilley - North Caldwell NJ
Kenneth Gregory Hull - Cambridge MA

Hoffmann-La Roche Inc. - Nutley NJ

A61K 314166

514341, 514386, 5462744, 5483225, 5483255

Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.

6600015, Jul 29, 2003

Mar 19, 2001

09/811964

Li Chen - Westfield NJ
Adrian Wai-Hing Cheung - Glen Rock NJ
Waleed Danho - Wayne NJ
Joseph Swistok - Nutley NJ
Keith Alan Yagaloff - HoHokus NJ

Hoffmann-La Roche Inc. - Nutley NJ

C07K 508

530331, 530330, 514 18

Peptides that selectively stimulate melanocortin-4 (MC-4) receptor activity are disclosed. In one embodiment, the peptides are of formula I:.

6756374, Jun 29, 2004

Jan 9, 2002

10/042619

Li Chen - Westfield NJ
Qingjie Ding - Bridgewater NJ
Paul Gillespie - Westfield NJ
Kyungjin Kim - Livingston NJ
Allen John Lovey - North Caldwell NJ
Warren William McComas - Denville NJ
Agostino Perrotta - Bloomfield NJ

Hoffmann-La Roche Inc. - Nutley NJ

A61K 31496

5142358, 5142531, 51425402, 544121, 544304, 544367

Disclosed are novel diaminothiazoles of formula wherein R , R , R , R and R are as herein disclosed. These compounds and their pharmaceutically acceptable salts and esters are selective inhibitors of Cdk4. As such, these compounds and their pharmaceutically acceptable salts and esters are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing the compounds of formula I and their pharmaceutically acceptable salts and esters, as well as intermediates useful in the preparation of the compounds of formula I.

6806365, Oct 19, 2004

Apr 5, 2002

10/117616

Li Chen - Westfield NJ
Robert William Guthrie - Saddle Brook NJ
Jefferson Wright Tilley - North Caldwell NJ
Kenneth Gregory Hull - Cambridge MA

Hoffmann-La Rocher Inc. - Nutley NJ

C07C22902

544169, 546323, 548214, 548253, 5483741, 548536, 549436, 552 10, 558406, 558415, 560 30, 562426, 562429, 562430, 562435, 562441, 562448, 562449

Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.

7045591, May 16, 2006

Aug 27, 2001

09/939966

Li Chen - Westfield NJ, US
Adrian Wai-Hing Cheung - Glen Rock NJ, US
Waleed Danho - Wayne NJ, US
Joseph Swistok - Nutley NJ, US
Yao Wang - Edison NJ, US
Keith Alan Yagaloff - Broad Brook CT, US

Hoffmann-La Roche Inc. - Nutley NJ

C07K 7/50

530317, 514 11, 514 17, 530318, 530328, 530330

Peptides cyclized via disulfide or lactam bridges are disclosed. The peptides exhibit melanocortin-4 receptor agonist activity and are useful for treating obesity.

7654672, Feb 2, 2010

Oct 31, 2008

12/263433

Huawei Zhao - Irvine CA, US
Li Chen - Santa Clara CA, US

Abbott Medical Optics Inc. - Santa Ana CA

A61B 3/10

351221, 351205

A system for providing vision contains an aberrometer, a wavefront sensor, and a transfer optical system. The aberrometer is configured to measure a received wavefront. The aberrometer includes a wavefront sensor and a transfer optical system for transferring an input wavefront so as to the provide the received wavefront at or near the wavefront sensor. The system also includes a processor in communication with the aberrometer, a readable memory, and instructions located within the memory. The readable memory contains one or more system error parameters and instructions available to the processor. The instructions are for determining at least one aberration of the received wavefront and calculating the input wavefront based on the received wavefront and the one or more system error parameters.

7875598, Jan 25, 2011

Mar 4, 2004

10/795554

Wenyuan Shi - Los Angeles CA, US
Li Chen - Los Angeles CA, US
Qing-yi Lu - Los Angeles CA, US
David Heber - Los Angeles CA, US
Maxwell H. Anderson - Seattle WA, US

The Regents of the University of California - Oakland CA

A61K 31/58
A61K 31/70
A01N 43/04
C07J 71/00

514172, 514 27, 540 17

The present invention is based on the discovery that certain chemical compounds isolated from Chinese medicinal herbs are useful as anti-microbial agents, e. g. , anti-bacterial agents, anti-fungal agents, and the like. In particular, the present invention provides compositions useful for treating microbial infections such as, for example, oral microbial infections, including periodontal disease and dental caries.