Li Chen

6455550, Sep 24, 2002

Aug 21, 1998

09/138353

Li Chen - Westfield NJ
Robert William Guthrie - Saddle Brook NJ
Jefferson Wright Tilley - North Caldwell NJ
Kenneth Gregory Hull - Cambridge MA

Hoffmann-La Roche Inc. - Nutley NJ

A61K 314166

514341, 514386, 5462744, 5483225, 5483255

Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.

6600015, Jul 29, 2003

Mar 19, 2001

09/811964

Li Chen - Westfield NJ
Adrian Wai-Hing Cheung - Glen Rock NJ
Waleed Danho - Wayne NJ
Joseph Swistok - Nutley NJ
Keith Alan Yagaloff - HoHokus NJ

Hoffmann-La Roche Inc. - Nutley NJ

C07K 508

530331, 530330, 514 18

Peptides that selectively stimulate melanocortin-4 (MC-4) receptor activity are disclosed. In one embodiment, the peptides are of formula I:.

6756374, Jun 29, 2004

Jan 9, 2002

10/042619

Li Chen - Westfield NJ
Qingjie Ding - Bridgewater NJ
Paul Gillespie - Westfield NJ
Kyungjin Kim - Livingston NJ
Allen John Lovey - North Caldwell NJ
Warren William McComas - Denville NJ
Agostino Perrotta - Bloomfield NJ

Hoffmann-La Roche Inc. - Nutley NJ

A61K 31496

5142358, 5142531, 51425402, 544121, 544304, 544367

Disclosed are novel diaminothiazoles of formula wherein R , R , R , R and R are as herein disclosed. These compounds and their pharmaceutically acceptable salts and esters are selective inhibitors of Cdk4. As such, these compounds and their pharmaceutically acceptable salts and esters are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing the compounds of formula I and their pharmaceutically acceptable salts and esters, as well as intermediates useful in the preparation of the compounds of formula I.

6806365, Oct 19, 2004

Apr 5, 2002

10/117616

Li Chen - Westfield NJ
Robert William Guthrie - Saddle Brook NJ
Jefferson Wright Tilley - North Caldwell NJ
Kenneth Gregory Hull - Cambridge MA

Hoffmann-La Rocher Inc. - Nutley NJ

C07C22902

544169, 546323, 548214, 548253, 5483741, 548536, 549436, 552 10, 558406, 558415, 560 30, 562426, 562429, 562430, 562435, 562441, 562448, 562449

Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.

7045591, May 16, 2006

Aug 27, 2001

09/939966

Li Chen - Westfield NJ, US
Adrian Wai-Hing Cheung - Glen Rock NJ, US
Waleed Danho - Wayne NJ, US
Joseph Swistok - Nutley NJ, US
Yao Wang - Edison NJ, US
Keith Alan Yagaloff - Broad Brook CT, US

Hoffmann-La Roche Inc. - Nutley NJ

C07K 7/50

530317, 514 11, 514 17, 530318, 530328, 530330

Peptides cyclized via disulfide or lactam bridges are disclosed. The peptides exhibit melanocortin-4 receptor agonist activity and are useful for treating obesity.

8126762, Feb 28, 2012

Apr 2, 2008

12/061029

Bala Ramachandran - Harrison NY, US
Li Chen - Palo Alto CA, US

International Business Machines Corporation - Armonk NY

G06F 17/30

705 728

A stabilization methodology and system component in Business Activity Monitoring and Management systems. This enables firms to use Business Activity Management (BAM) systems to manage business activity by only responding to monitored data when the overall business performance can be improved. This enables firms to identify appropriate tradeoffs between potentially conflicting objectives while meeting business objectives. Information from BAM systems are analyzed based on models of the business process and different information filter criteria are assessed for their impact on business performance indicators. Based on this, a filter criterion is chosen which is executed by an information filter. The outputs from the information filter are used as the basis for deciding the inputs for business process execution.

20030229200, Dec 11, 2003

May 9, 2003

10/435466

Li Chen - Westfield NJ, US
Adrian Cheung - Glen Rock NJ, US
Waleed Danho - Wayne NJ, US
Joseph Swistok - Nutley NJ, US
Keith Yagaloff - Hohokus NJ, US

C07K007/06
A61K038/08

530/330000, 514/017000

Peptides of formulae I, II and III that selectively activate melanocortin-4 (MC-4) receptor activity.

20040210051, Oct 21, 2004

Apr 21, 2004

10/828771

Li Chen - Westfield NJ, US
Robert Guthrie - Saddle Brook NJ, US
Jefferson Tilley - North Caldwell NJ, US
Kenneth Hull - Cambridge MA, US

C07D279/12
C07D277/04
C07D263/34
C07D211/32

544/059000, 544/162000, 544/386000, 546/225000, 548/200000, 548/236000, 548/333500, 548/530000

Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.