Lei P Wu

20050148034, Jul 7, 2005

Apr 14, 2003

10/511354

Robert Hariri - Florham Park NJ, US
Faribourz Payvandi - Belle Mead NJ, US
Lei Wu - Bridgewater NJ, US
David Stirling - Branchburg NJ, US
Qian Ye - Livingston NJ, US

G01N033/574
C12N005/08

435007230, 435366000

The present invention relates to methods of identifying modulators of angiogenesis utilizing human cells. The methods of the invention can be employed to assay compounds and small molecules for their ability to modulate human angiogenesis utilizing human pluripotent stem cells in an in vitro assay system. The present invention further relates to methods of identifying modulators of human angiogenesis by determining the ability of a test compound to modulate spontaneous vasogenesis in an in vitro assay system utilizing nonembryonic pluripotent stem cells. The present invention relates to in vitro assay systems utilizing nonembryonic pluripotent stem cells for the identification of compounds that modulate human angiogenesis or human vasogenesis. The present invention also relates to methods of treatment which require modulation of human angiogenesis or vasogenesis comprising administering to patients in need of such treatment compounds or small molecules which have been identified to be inhibitors of human angiogenesis or vasogenesis.

20140008210, Jan 9, 2014

Mar 15, 2013

13/844085

Douglas T. YAMANISHI - Huntington Beach CA, US
Andrea GHETTI - San Diego CA, US
Guoliang TAO - San Diego CA, US
Huimin TAO - San Diego CA, US
Ky TRUONG - San Diego CA, US
Lei WU - San Diego CA, US
Xiaobo WANG - San Diego CA, US

G01N 1/34
B01D 29/00

20415821, 210506, 204660, 210251, 210143, 210767, 204518, 210695, 210774, 204554, 4272481, 427180, 427181, 427569, 42725528

The present invention provides a filtration chamber comprising a microfabricated filter enclosed in a housing, wherein the surface of said filter and/or the inner surface of said housing are modified by vapor deposition, sublimation, vapor-phase surface reaction, or particle sputtering to produce a uniform coating; and a method for separating cells of a fluid sample, comprising: a) dispensing a fluid sample into the filtration chamber disclosed herein; and b) providing fluid flow of the fluid sample through the filtration chamber, wherein components of the fluid sample flow through or are retained by the filter based on the size, shape, or deformability of the components.

20140073536, Mar 13, 2014

Sep 13, 2013

14/027044

Douglas T. YAMANISHI - Huntington Beach CA, US
George WALKER - San Diego CA, US
Junquan XU - San Diego CA, US
Mingxian HUANG - San Diego CA, US
Guoliang TAO - San Diego CA, US
Lei WU - San Diego CA, US
Xiaobo WANG - San Diego CA, US
Joe OUYANG - San Diego CA, US
Jing CHENG - Beijing, CN
Jia XU - Washington DC, US

G01N 1/34

506 16, 435 34, 435 611, 435 612

The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells, especially tumor cells, from a complex fluid sample such as a blood sample. In particular, the present invention is directed to methods and compositions for detecting a non-hematopoietic cell, e.g., a non-hematopoietic tumor cell, in a blood sample via, inter alia, removing red blood cells (RBCs) from a blood sample using a non-centrifugation procedure, removing white blood cells (WBCs) from said blood sample to enrich a non-hematopoietic cell, if any, from said blood sample; and assessing the presence, absence and/or amount of said enriched non-hematopoietic cell.

20170089814, Mar 30, 2017

Dec 15, 2016

15/380981

- San Diego CA, US
Douglas T. YAMANISHI - Huntington Beach CA, US
George WALKER - San Diego CA, US
Junquan XU - San Diego CA, US
Mingxian HUANG - San Diego CA, US
Guoliang TAO - San Diego CA, US
Lei WU - San Diego CA, US
Xiaobo WANG - San Diego CA, US
Joe OUYANG - San Diego CA, US
Jing CHENG - Beijing, CN
Jia XU - Washington DC, US

AVIVA BIOSCIENCES CORPORATION - San Diego CA

G01N 1/40
G01N 35/10
C12Q 1/68
G01N 33/569
A61B 5/15
B01L 3/00
B01D 61/18
B01D 67/00
G01N 15/02
G01N 15/05
G01N 35/02
G01N 35/04

The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells, especially tumor cells, from a complex fluid sample such as a blood sample. In particular, the present invention is directed to methods and compositions for detecting a non-hematopoietic cell, e.g., a non-hematopoietic tumor cell, in a blood sample via, inter alia, removing red blood cells (RBCs) from a blood sample using a non-centrifugation procedure, removing white blood cells (WBCs) from said blood sample to enrich a non-hematopoietic cell, if any, from said blood sample; and assessing the presence, absence and/or amount of said enriched non-hematopoietic cell.

20160040232, Feb 11, 2016

Mar 2, 2015

14/636032

- San Diego CA, US
Douglas T. YAMANISHI - Huntington Beach CA, US
George WALKER - San Diego CA, US
Junquan XU - San Diego CA, US
Mingxian HUANG - San Diego CA, US
Guoliang TAO - San Diego CA, US
Lei WU - San Diego CA, US
Xiaobo WANG - San Diego CA, US
Joe OUYANG - San Diego CA, US
Jing CHENG - Beijing, CN
Jia XU - Washington DC, US

AVIVA BIOSCIENCES CORPORATION - San Diego CA

C12Q 1/68
G01N 33/569

The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells, especially tumor cells, from a complex fluid sample such as a blood sample. In particular, the present invention is directed to methods and compositions for detecting a non-hematopoietic cell, e.g., a non-hematopoietic tumor cell, in a blood sample via, inter alia, removing red blood cells (RBCs) from a blood sample using a non-centrifugation procedure, removing white blood cells (WBCs) from said blood sample to enrich a non-hematopoietic cell, if any, from said blood sample; and assessing the presence, absence and/or amount of said enriched non-hematopoietic cell.