Inventors:
Shiu Nan Chen - San Marino CA, US
Chung Lun Lu - San Marino CA, US
Jung Fu Wu - San Marcos CA, US
Sherwin Chen - San Marino CA, US
International Classification:
C12P 21/04
C12N 9/02
Abstract:
A fibrinolytic enzyme isolated from a culture broth of a mushroom has a characteristic of degrading a fibrin and a fibrinogen without activating an activity of a plasminogen. The plasminogen is activated to generate a plasmin to degrade the fibrin and/or fibrinogen, so that the fibrinolytic enzyme be used for the thrombosis-related diseases to degrade the fibrin and fibrinogen of blood clots without activate the plasminogen, so as to avoid a hemorrhage due to the over activation the plasminogen to over generate the plasmin.
