Jun Wen Phones & Addresses
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Plainsboro, NJ
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East Brunswick, NJ
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Dayton, NJ
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Hamilton Square, NJ
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West Lafayette, IN
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Keasbey, NJ
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New Haven, CT
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Louisville, KY
Publications
Us Patents
N-Heterocyclic Inhibitors Of Tnf-Alpha Expression
View pageUS Patent:
8044040, Oct 25, 2011
Filed:
Jul 16, 2007
Appl. No.:
11/778219
Inventors:
Gulzar Ahmed - Yardley PA, US
Axel Metzger - East Windsor NJ, US
Ian Henderson - Hopewell NJ, US
David J. Diller - Hightstown NJ, US
Jun Wen - Dayton NJ, US
Stephen T. Wrobleski - Whitehouse Station NJ, US
Katerina Leftheris - Skillman NJ, US
Chunjian Liu - Pennington NJ, US
Axel Metzger - East Windsor NJ, US
Ian Henderson - Hopewell NJ, US
David J. Diller - Hightstown NJ, US
Jun Wen - Dayton NJ, US
Stephen T. Wrobleski - Whitehouse Station NJ, US
Katerina Leftheris - Skillman NJ, US
Chunjian Liu - Pennington NJ, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
Pharmacopeia, Inc. - Cranbury NJ
Pharmacopeia, Inc. - Cranbury NJ
International Classification:
C07D 239/48
A61K 31/505
A61K 31/505
US Classification:
514218, 514256, 514274, 514275, 540575, 544317, 544323, 544324, 544326, 544328, 544329
Abstract:
N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I):.
N-Heterocyclic Inhibitors Of Tnf-Alpha Expression
View pageUS Patent:
20060276488, Dec 7, 2006
Filed:
Jul 12, 2006
Appl. No.:
11/485075
Inventors:
Gulzar Ahmed - Yardley PA, US
Axel Metzger - East Windsor NJ, US
Ian Henderson - Hopewell NJ, US
David Diller - Hightstown NJ, US
Jun Wen - Dayton NJ, US
Stephen Wrobleski - Whitehouse Station NJ, US
Katerina Leftheris - Skillman NJ, US
Chunjian Liu - Pennington NJ, US
Axel Metzger - East Windsor NJ, US
Ian Henderson - Hopewell NJ, US
David Diller - Hightstown NJ, US
Jun Wen - Dayton NJ, US
Stephen Wrobleski - Whitehouse Station NJ, US
Katerina Leftheris - Skillman NJ, US
Chunjian Liu - Pennington NJ, US
International Classification:
A61K 31/505
C07D 239/48
C07D 239/48
US Classification:
514256000, 514275000, 544323000
Abstract:
N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I): Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.