John Vu

20220257258, Aug 18, 2022

Apr 27, 2022

17/730625

- Aliso Viejo CA, US
Parker Milhous - Santa Ana CA, US
Joseph Emery - Riverside CA, US
Hung Tran - Midway City CA, US
John Vu - Santa Ana CA, US
Hussain S. Rangwala - Villa Park CA, US
William R. Patterson - Huntington Beach CA, US

A61B 17/12

Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant such as a permeable shell or mesh having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The permeable implant may include a stiffer proximal portion that is configured to sit at the neck of an aneurysm. The stiffer proximal portion may include additional mesh layers on either the inside or the outside of a first permeable shell. The distal portion of the device may be softer and deformable.

20220257260, Aug 18, 2022

Dec 14, 2021

17/550085

- Aliso Viejo CA, US
Joseph Emery - Riverside CA, US
Hung Tran - Midway City CA, US
John Vu - Santa Ana CA, US
Karishma Desai - Irvine CA, US
Parker Milhous - Santa Ana CA, US

A61B 17/12

Devices and methods for treatment of a patient's vasculature are described. Embodiments may include an implant having multiple mesh layers. A first and second layer of the implant may be formed by folding over a single mesh and the third layer may be formed from a different mesh. The first, second, and third layers may be either a stasis or a structural layer and may be arranged in different orders. Embodiments may also include structures to assist in the expansion of the device. These structures may include an expandable loop or reinforcing finger extensions. Embodiments may also include a corrugation or ridge around a middle section of the implant to assist in deployment.

20220251162, Aug 11, 2022

Oct 25, 2021

17/510090

- Oakland CA, US
- Washington DC, US
John P. Vu - Los Angeles CA, US

The Regents of the University of California - Oakland CA
The United States Government Represented by The Department Of Veterans Affairs - Washington DC

C07K 14/575
A61K 47/61
A61K 47/65
A61K 47/60
A61K 31/4985
A61K 38/22
C07K 14/435

In certain embodiments novel PAC1 receptor agonists are provided wherein the agonists comprise a targeting sequence that binds to the PAC1 receptor and said targeting sequence is attached to an amino acid sequence comprising a fragment of the maxadilan amino acid sequence, wherein the targeting sequence comprises a full-length 38 amino acid PACAP peptide or an N-terminus fragment thereof containing the amino acid sequence HSDGIF, wherein said targeting sequence optionally comprises an amino acid insertion between residues 11 and 12 of said PACAP peptide or fragment thereof; and the fragment of the maxadilan amino acid sequence comprises a fragment of the maxadilan sequence effective to activate PAC1 signaling.

20230114169, Apr 13, 2023

Aug 26, 2022

17/896620

- Aliso Viejo CA, US
Parker Milhous - Santa Ana CA, US
Hung P. Tran - Midway City CA, US
John Vu - Santa Ana CA, US
Hussain S. Rangwala - Villa Park CA, US
Hiroshi Shiono - Aliso Viejo CA, US

A61B 17/12

Devices and methods for treatment of a patient’s vasculature are described. Embodiments may include a permeable implant having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The implant may include a cavity in a proximal section that may optionally house embolic material, such as coils. Alternatively, the implant may have an expanded preset shape that is different than an expanded preset shape that is assumed after deployment in an aneurysm. The expanded preset shape may be frustoconical. Alternatively, the implant may include an outer skirt coupled to a proximal section of the permeable implant.

20200289126, Sep 17, 2020

Mar 12, 2020

16/817032

- Aliso Viejo CA, US
Parker Milhous - Santa Ana CA, US
Joseph Emery - Riverside CA, US
Hung Tran - Midway City CA, US
John Vu - Santa Ana CA, US
Hussain S. Rangwala - Villa Park CA, US
William R. Patterson - Huntington Beach CA, US

A61B 17/12

Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant such as a permeable shell or mesh having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The permeable implant may include a stiffer proximal portion that is configured to sit at the neck of an aneurysm. The stiffer proximal portion may include additional mesh layers on either the inside or the outside of a first permeable shell. The distal portion of the device may be softer and deformable.

20190322718, Oct 24, 2019

Jan 4, 2018

16/473240

- Oakland CA, US
- Washington DE, US
John P. Vu - Los Angeles CA, US

C07K 14/575
C07K 14/435
A61K 47/60
A61K 47/65
A61K 47/61
A61K 38/22
A61K 31/4985

In certain embodiments novel PAC1 receptor agonists are provided wherein the agonists comprise a targeting sequence that binds to the PAC1 receptor and said targeting sequence is attached to an amino acid sequence comprising a fragment of the maxadilan amino acid sequence, wherein the targeting sequence comprises a full-length 38 amino acid PACAP peptide or an N-terminus fragment thereof containing the amino acid sequence HSDGIF, wherein said targeting sequence optionally comprises an amino acid insertion between residues 11 and 12 of said PACAP peptide or fragment thereof; and the fragment of the maxadilan amino acid sequence comprises a fragment of the maxadilan sequence effective to activate PAC1 signaling.