Joan A Davies

20080050746, Feb 28, 2008

Aug 14, 2007

11/893356

Gary McMaster - Ann Arbor MI, US
Joan Davies - Los Gatos CA, US
Yunqing Ma - Cupertino CA, US
Yuling Luo - San Ramon CA, US

Panomics, Inc. - Fremont CA

C12N 5/02
C12Q 1/68

435006000, 435383000

This invention provides methods of quantitating nucleic acids from problematic samples, such as aged samples, formalin fixed samples, paraffin embedded samples, samples with aneuploid cells, and cells with fragmented nucleic acids. Methods include techniques to efficiently solublize the nucleic acids under non-denaturing conditions from preserved clinical samples without resort to organic extractions, to normalize cell counts regardless of aneuploidy, to access the fragmentation state of the nucleic acids, and to provide standard curves for degraded nucleic acid samples.

20110223606, Sep 15, 2011

May 17, 2011

13/068727

Gary McMaster - Ann Arbor MI, US
Joan Davies - Los Gatos CA, US
Yunqing Ma - Cupertino CA, US
Yuling Luo - San Ramon CA, US

Panomics, Inc. - Fremont CA

C12Q 1/68
G01J 3/00
G01J 1/58

435 612, 435 61, 204456, 356319, 2504591

This invention provides methods of quantitating nucleic acids from problematic samples, such as aged samples, formalin fixed samples, paraffin embedded samples, samples with aneuploid cells, and cells with fragmented nucleic acids. Methods include techniques to efficiently solubilize the nucleic acids under non-denaturing conditions from preserved clinical samples without resort to organic extractions, to normalize cell counts regardless of aneuploidy, to access the fragmentation state of the nucleic acids, and to provide standard curves for degraded nucleic acid samples.