Jing Fang Wu

52120821, May 18, 1993

Mar 13, 1991

7/669446

Menek Goldstein - New York NY
Jing Wu - New York NY
David Filer - New York NY
Arnold J. Friedhoff - New York NY

New York University - New York NY

C12N 904
C12N 1500

435190

Modification of the DNA encoding the enzyme tyrosine hydroxylase (TH) resulting in amino acid substitution in one of the first fifty five N-terminal residues, in particular replacing Ser-40 with Tyr or Leu, produced TH variants having substantially increased enzymatic activity upon transfection of suitable host cells. Cells transfected with the variant TH having enhanced enzymatic activity are useful for treating neurological or psychiatric disorders associated with deficient TH or dopamine, in particular Parkinson's disease, by grafting such cells into the brain.

53004361, Apr 5, 1994

Jan 26, 1993

8/009075

Menek Goldstein - New York NY
Jing Wu - New York NY
David Filer - New York NY
Arnold J. Friedhoff - New York NY

New York University - New York NY

C12N 1500
C12N 904

4352523

Modification of the DNA encoding the enzyme tyrosine hydroxylase (TH) resulting in amino acid substitution in one of the first fifty five N-terminal residues, in particular replacing Ser-40 with Tyr or Leu, produced TH variants having substantially increased enzymatic activity upon transfection of suitable host cells. Cells transfected with the variant TH having enhanced enzymatic activity are useful for treating neurological or psychiatric disorders associated with deficient TH or dopamine, in particular Parkinson's disease, by grafting such cells into the brain.