Inventors:
Bob G. Sanders - Austin TX, US
Kimberly Kline - Austin TX, US
Weiping Yu - Austin TX, US
Hui Liu - Houston TX, US
Feras Hantash - Dana Point CA, US
Assignee:
Research Development Foundation - Carson City NV
International Classification:
C12N 9/02
C12N 1/20
C12N 15/00
C07K 1/00
C07H 21/04
US Classification:
435189, 435 4, 435 6, 4352523, 4353201, 4352528, 435440, 536 232, 536 237, 536 234, 530350
Abstract:
The present invention provides a novel tocopherol associated protein (TAP-38) DNA/protein with a 76 nucleotide base deletion resulting in a 25 amino acid deletion, followed by 90 novel nucleotides that code for 30 novel amino acids that are not expressed by TAP-46. The present invention provides data showing that TAP-38 enhances the apoptotic inducing properties of tocopherol based compounds, and blockage of TAP reduces the effectiveness of tocopherol based compounds. Thus, the present invention claim that expression of TAP-38 by tumor cells enhances the apoptotic inducing properties of tocopherol based compounds. The present invention provides aerosol liposome/transfection/infection methods for delivery of TAP-38 and TAP-46 cDNA plasmids separately and in combination with tocopherol based apoptotic inducing agents as well as with other chemotherapeutic agents as a method for treatment and prevention of cellular proliferative diseases and disorders.