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Hong So Cai

from Los Alamos, NM
Age ~59
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Also known as:
Hong Lai, Cheng Cai
Phone and address:
2306 Canyon Glen Rd, Los Alamos, NM 87544
(505) 662-9772
Related to:
Anna Man Lam, 58Ziying Cai
Connected to:
Anping Cai, 46Bao K Cai, 67Beibei Cai, 35Biaodong Cai, 62Caitlin Cai, 34Cecilia Y Cai, 35Changqing Cai, 58Chao Cai, 45Chunli Cai, 52Cristina Cai, 41

Hong Cai Phones & Addresses

  • 2306 Canyon Glen Rd, Los Alamos, NM 87544 (505) 662-9772
  • 1997 Cumbres Patio St, Los Alamos, NM 87544 (505) 662-9772
  • Solana Beach, CA
  • Santa Fe, NM
  • San Diego, CA
  • Pasadena, CA
  • Los Angeles, CA

Work

Position: Professional/Technical

Education

Degree: Graduate or professional degree

Resumes

Resumes

Hong Cai Photo 1

Co-Founder And Chief Technology Officer

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Location:
2306 Canyon Glen Rd, Los Alamos, NM 87544
Industry:
Biotechnology
Work:
Mesa Biotech, Inc
Chief Executive Officer, President at Mesa Biotech, Inc Formely Mesa Technician International, Inc
Los Alamos National Laboratory 1995 - 2009
Principle Investigator and Staff Scientist
Mesa Tech International 1995 - 2009
Co-Founder and Chief Technology Officer
Education:
University of Southern California 1982 - 1995
Doctorates, Doctor of Philosophy, Molecular Biology, Philosophy Peking University 1984 - 1988
Bachelors, Bachelor of Science, Biology
Skills:
Molecular Biology
Genomics
Assay Development
Infectious Diseases
Biotechnology
R&D
Pcr
Biochemistry
Science
Dna
Protein Expression
Protein Chemistry
Molecular Diagnostics
Genetics
Bioinformatics
Lifesciences
High Throughput Screening
Laboratory
Cell Biology
Proteomics
Microbiology
Cell Culture
Immunology
Flow Cytometry
Protein Purification
Cell
Microscopy
Sequencing
Technology Transfer
Dna Sequencing
Elisa
Drug Discovery
Western Blotting
Qpcr
Cancer
Protein Engineering
Enzyme Kinetics
Fluorescence
Dna Extraction
Rna Isolation
Cancer Research
Molecular Cloning
Systems Biology
Hplc
Transfection
Biophysics
Gel Electrophoresis
Tissue Culture
Computational Biology
Project Management
Languages:
English
Mandarin
Certifications:
Innovative Customer Service Techniques
Hong Cai Photo 2

Hong Cai

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Hong Cai Photo 3

Hong Cai

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Hong Cai Photo 4

Hong Cai

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Location:
United States
Hong Cai Photo 5

Sr. Software Engneer At Medimpact

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Location:
Greater San Diego Area
Industry:
Pharmaceuticals

Business Records

Name / Title
Company / Classification
Phones & Addresses
Hong Cai
President
MESA US GROUP, INC
2306 Cyn Gln Rd   , Los Alamos, NM 87544
Hong Cai
Chief Executive Officer
Mesa Tech International, Inc
Biotechnology Development
2306 Cyn Gln Rd, Los Alamos, NM 87544
(505) 662-9772
Hong Cai
Treasurer
AMERICAN DL GROUP, INC
923 E Vly Blvd #202, San Gabriel, CA 91776

Publications

Us Patents

Quenching Methods For Background Reduction In Luminescence-Based Probe-Target Binding Assays

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US Patent:
7202036, Apr 10, 2007
Filed:
Jun 12, 2003
Appl. No.:
10/460451
Inventors:
Hong Cai - Los Alamos NM, US
Peter M Goodwin - Los Alamos NM, US
Richard A. Keller - Los Alamos NM, US
Rhiannon L. Nolan - Santa Fe NM, US
Assignee:
Los Alamos National Security, LLC - Los Alamos MN
International Classification:
C12Q 1/68
US Classification:
435 6
Abstract:
Background luminescence is reduced from a solution containing unbound luminescent probes, each having a first molecule that attaches to a target molecule and having an attached luminescent moiety, and luminescent probe/target adducts. Quenching capture reagent molecules are formed that are capable of forming an adduct with the unbound luminescent probes and having an attached quencher material effective to quench luminescence of the luminescent moiety. The quencher material of the capture reagent molecules is added to a solution of the luminescent probe/target adducts and binds in a proximity to the luminescent moiety of the unbound luminescent probes to quench luminescence from the luminescent moiety when the luminescent moiety is exposed to exciting illumination. The quencher capture reagent does not bind to probe molecules that are bound to target molecules and the probe/target adduct emission is not quenched.

Dna Polymorphism Identity Determination Using Flow Cytometry

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US Patent:
20020015962, Feb 7, 2002
Filed:
Sep 11, 2001
Appl. No.:
09/953534
Inventors:
John Nolan - Santa Fe NM, US
P. White - Los Alamos NM, US
Hong Cai - Los Alamos NM, US
International Classification:
C12Q001/68
C12P019/34
US Classification:
435/006000, 435/007500, 435/091200
Abstract:
DNA polymorphism identity determination using flow cytometry. Primers designed to be immobilized on microspheres are allowed to anneal to the DNA strand under investigation, and are extended by either DNA polymerase using fluorescent dideoxynucleotides or ligated by DNA ligase to fluorescent reporter oligonucleotides. The fluorescence of either the dideoxynucleotide or the reporter oligonucleotide attached to the immobilized primer is measured by flow cytometry, thereby identifying the nucleotide polymorphism on the DNA strand.

Rapid Haplotyping By Single Molecule Detection

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US Patent:
20060008799, Jan 12, 2006
Filed:
May 21, 2001
Appl. No.:
09/862855
Inventors:
Hong Cai - Los Alamos NM, US
Peter Goodwin - Los Alamos NM, US
Richard Keller - Los Alamos NM, US
James Werner - Los Alamos NM, US
International Classification:
C12Q 1/68
US Classification:
435006000
Abstract:
The present invention includes a method for rapid haplotyping a DNA or RNA segment. Two or more target sites on a segment of DNA or RNA are labeled with separate distinguishable luminescent hybridization probes, where the targets are selected genetic markers. A dilute solution is formed containing the labeled DNA or RNA segments. Each DNA or RNA segment is illuminated with light beams effective to excite each luminescent hybridization probe, when present. The presence or absence of each luminescent hybridization probe on each DNA or RNA segment is detected to determine the haplotype of each DNA or RNA segment.

Oscillating Amplification Reaction For Nucleic Acids

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US Patent:
20140045221, Feb 13, 2014
Filed:
Apr 20, 2012
Appl. No.:
14/113200
Inventors:
Hong Cai - Santa Fe NM, US
Nathan J. Cobb - Durham NC, US
Assignee:
MESA TECH INTERNATIONAL, INC. - San Diego CA
International Classification:
C12P 19/34
US Classification:
435 915, 435194
Abstract:
One embodiment of the present invention provides for a method for amplifying a template of nucleic acid target sequence contained in a sample. The method includes contacting the sample with an amplification reaction mixture containing a primer complementary to the template of nucleic acid target sequence. A temperature of the reaction is oscillated between an upper temperature and a lower temperature wherein the change in temperature is no greater than about 20 C. during a plurality of temperature cycles. The template of nucleic acid target sequence is amplified.

Dna Polymorphism Identity Determination Using Flow Cytometry

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US Patent:
62877666, Sep 11, 2001
Filed:
Oct 28, 1998
Appl. No.:
9/182869
Inventors:
John P. Nolan - Santa Fe NM
P. Scott White - Los Alamos NM
Hong Cai - Los Alamos NM
Assignee:
The Regents of the University of California - Los Alamos NM
International Classification:
C12Q 168
C12P 1500
C07H 2102
C07H 2104
C12N 1500
US Classification:
435 6
Abstract:
DNA polymorphism identity determination using flow cytometry. Primers designed to be immobilized on microspheres are allowed to anneal to the DNA strand under investigation, and are extended by either DNA polymerase using fluorescent dideoxynucleotides or ligated by DNA ligase to fluorescent reporter oligonucleotides. The fluorescence of either the dideoxynucleotide or the reporter oligonucleotide attached to the immobilized primer is measured by flow cytometry, thereby identifying the nucleotide polymorphism on the DNA strand.

Hierarchical Supervised Training For Neural Networks

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US Patent:
20230004812, Jan 5, 2023
Filed:
Jun 24, 2022
Appl. No.:
17/808949
Inventors:
- San Diego CA, US
Hong CAI - San Diego CA, US
Yizhe ZHANG - San Diego CA, US
Fatih Murat PORIKLI - San Diego CA, US
International Classification:
G06N 3/08
G06K 9/62
Abstract:
Certain aspects of the present disclosure provide techniques for training neural networks using hierarchical supervision. An example method generally includes training a neural network with a plurality of stages using a training data set and an initial number of classification clusters into which data in the training data set can be classified. A cluster-validation set performance metric is generated for each stage based on a reduced number of classification clusters relative to the initial number of classification clusters and a validation data set. A number of classification clusters to implement at each stage is selected based on the cluster-validation set performance metric and an angle selected relative to the cluster-validation set performance metric for a last stage of the neural network. The neural network is retrained based on the training data set and the selected number of classification clusters for each stage, and the trained neural network is deployed.

Fluidic Test Cassette

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US Patent:
20180304260, Oct 25, 2018
Filed:
Apr 20, 2018
Appl. No.:
15/958958
Inventors:
- San Diego CA, US
Hong Cai - Los Alamos NM, US
Robert B. Cary - Santa Fe NM, US
Assignee:
Mesa Biotech, Inc. - San Diego CA
International Classification:
B01L 3/00
G01N 33/543
C12Q 1/6825
C12Q 1/6806
C12Q 1/6809
Abstract:
A disposable cassette for detecting nucleic acids or performing other assays. The cassette can be inserted into a base station during use. The cassette has numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. The vent pockets have protrusions to help prevent accidental resealing. The cassette also can have a gasket to ensure free air movement between open vent pockets. A flexible circuit with patterned metallic electrical components disposed on a heat stable material can be in direct contact with fluid in the chambers and has resistive heating elements aligned with the vent pockets and the chambers. Recesses in the cassette channels or chambers can have structures such as ridges or grooves to direct fluid flow to enhance rehydration of lyophilized reagents disposed in the recess. Flow diverters in the chambers can reduce the flow velocity of the sample fluid and increase the effective fluid flow path length, enabling more accurate control of fluid flow in the cassette. The roof of each chamber can have a projection that prevents capillary fluid flow across the top of the chamber, thus reducing or preventing sequestration of newly resuspended reagent from the bulk of the reaction solution volume.

Fluidic Test Cassette

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US Patent:
20160310948, Oct 27, 2016
Filed:
Apr 25, 2016
Appl. No.:
15/137983
Inventors:
- San Diego CA, US
Michael Wang - San Diego CA, US
Robert B. Cary - Santa Fe NM, US
Hong Cai - Los Alamos NM, US
Conrad Lindberg - Fallbrook CA, US
Martin Bouliane - Carlsbad CA, US
Donald J. Thomas - Vista CA, US
International Classification:
B01L 7/00
C12Q 1/68
B01L 3/00
Abstract:
A disposable cassette for detecting nucleic acids or performing other assays. The cassette can be inserted into a base station during use. The cassette has numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. The vent pockets have protrusions to help prevent accidental resealing. The cassette also can have a gasket to ensure free air movement between open vent pockets. A flexible circuit with patterned metallic electrical components disposed on a heat stable material can be in direct contact with fluid in the chambers and has resistive heating elements aligned with the vent pockets and the chambers. The detection chamber, which houses a lateral flow detection strip can have a space below the strip that has sufficient capacity to accommodate an entire volume of the sample fluid entering the detection chamber at a height that enables the fluid to flow up the detection strip by capillary action without flooding or otherwise bypassing regions of the detection strip. The space can also contain detection particles. Recesses in in the cassette channels or chambers can have structures such as ridges or grooves to direct fluid flow to enhance rehydration of lyophilized reagents disposed in the recess. Flow diverters in the chambers can reduce the flow velocity of the sample fluid and increase the effective fluid flow path length, enabling more accurate control of fluid flow in the cassette.
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Hong So Cai from Los Alamos, NM, age ~59 Get Report