Hao Wu

8450454, May 28, 2013

Jan 13, 2011

13/006309

Shi Du Yan - Tenafly NJ, US
David M. Stern - Cincinnati OH, US
Joyce W. Lustbader - Tenafly NJ, US
Hao Wu - New York NY, US

The Trustees of Columbia University in the City of New York - New York NY

C07K 2/00
C07K 4/00
C07K 5/00
C07K 7/00
C07K 14/00

530300, 530350, 530324, 436 89

This invention provides methods, compositions and articles of manufacture for inhibiting binding between Aβ protein and ABAD in cells. Uses of this invention include, for example, treating Alzheimer's disease; reducing free radical generation, DNA fragmentation, and cytochrome C release in cells; and preserving cell viability by preventing LDH release from a cell.

20080274975, Nov 6, 2008

Apr 12, 2005

11/578401

Shi Du Yan - Tenafly NJ, US
David M. Stern - Augusta GA, US
Joyce W. Lustbader - Tenafly NJ, US
Hao Wu - New York NY, US

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YOURK - New York NY
CORNELL RESEARCH FOUNDATION, INC. - Ithaca NY

A61K 38/10
C07K 7/08
C12N 5/00
A61P 25/28

514 13, 530326, 435375

This invention provides methods, compositions and articles of manufacture for inhibiting binding between Aβ protein and ABAD in cells. Uses of this invention include, for example, treating Alzheimer's disease; reducing free radical generation, DNA fragmentation, and cytochrome C release in cells; and preserving cell viability by preventing LDH release from a cell.

20190263785, Aug 29, 2019

Oct 31, 2017

16/346483

- Ithaca NY, US
- Boston MA, US
Gabriella Casalena - New York NY, US
Nathanael S. Gray - Boston MA, US
David A. Scott - Newton MA, US
John Hatcher - Marlborough MA, US
Guangyan Du - Jamaica Plain MA, US
Hao Wu - Brookline MA, US
Qi Qiao - Brighton MA, US

Cornell University - Ithaca NY
Dana-Farber Cancer Institute ,Inc. - Boston MA
Children's Medical Center Corporation - Boston MA

C07D 401/14
C07D 417/14
C07D 471/04
C07D 487/04
A61K 31/519
A61K 31/4439
A61P 35/00

Provided herein are bifunctional compounds that inhibit MALT1 and/or promote targeted ubiquitination for the degradation of MALT1. In particular, provided are compounds that can bind MALT1, a protein whose activity is responsible for constitutive NF-KB signaling in certain cancers (e.g., activated B-cell diffuse large B-cell lymphoma (ABC-DLBCL)), and can assist in its degradation by recruiting an E3 ubiquitin ligase (e.g., Cereblon, VHL), which can ubiquitinate MALT1, marking it for proteasome degradation. Also provided are pharmaceutical compositions comprising the bifunctional compounds, methods of treating cancer with the bifunctional compounds, methods of promoting the degradation of MALT1, and methods of binding E3 ubiquitin ligase activity in a subject by administering a compound or composition described herein.

20180268982, Sep 20, 2018

Mar 5, 2018

15/911778

- New York NY, US
Ryan Davies - New York NY, US
Hao Wu - New York NY, US

H01F 27/24
H01L 49/02
H01F 27/28
H01F 13/00
H01F 41/14
H01F 41/06
H01F 27/38
H01F 1/147
H01F 27/255
H01F 17/06
H01F 17/04
H01F 17/00

Inductive elements comprising anisotropic media and biasing coils for magnetically biasing thereof and methods of manufacture and operation for use in applications such as microelectronics. Application of an electrical current through the bias coils generates a magnetic field that biases the magnetic material such that a desirable orientation of anisotropy is achieved throughout the magnetic core and enables modulation of the inductive response of the device. Electrical conductors coupled to interconnects are magnetically coupled to magnetic core layers to produce self and/or mutual inductors.

20180219420, Aug 2, 2018

Jul 18, 2017

15/652552

- Eden Prairie MN, US
Hao Wu - Los Angeles CA, US
Ruogu Wang - Eden Prairie MN, US

Wardenclyffe LLC - Eden Prairie MN

H02J 50/12
H02J 50/40
H02J 7/02

A new resonance-based wireless power transfer system is disclosed. The new resonance-based wireless power transfer system includes a power transmitter and a power receiver. The power transmitter and the power receiver are both oscillator-based circuits, but unlike prior systems, their resonant frequencies are different. The difference between the transmitter's resonant frequency and the receiver's resonant frequency is set between a lower bound and an upper bound to ensure that the new resonance-based wireless power transfer system will have only one oscillation frequency while maintaining high power transfer efficiency over varied distances.

20180182530, Jun 28, 2018

Dec 27, 2016

15/391278

- New York NY, US
Ryan Davies - New York NY, US
Hao Wu - New York NY, US
Michael Lekas - New York NY, US

H01F 27/25
H01F 27/28

An inductor includes a magnetic core lying in a core plane. The magnetic core includes a vertical laminated structure with respect to the core plane of alternating ferromagnetic vertical layers and insulator vertical layers. An easy axis of magnetization can be permanently or semi-permanently fixed in the ferromagnetic vertical layers along an axis orthogonal to the core plane. Methods of manufacturing same are also disclosed.

20180182841, Jun 28, 2018

Jan 30, 2017

15/419562

- New York NY, US
Ryan Davies - New York NY, US
Hao Wu - New York NY, US
Michael Lekas - New York NY, US

H01L 49/02
H01L 23/522
H01L 23/528
H01L 21/3205
H01L 21/288
H01L 21/027
H01F 27/24
H01F 27/28
H01F 41/04

Methods of manufacturing are disclosed for an inductor that includes a magnetic core lying in a core plane. The magnetic core includes a vertical laminated structure with respect to the core plane of alternating ferromagnetic vertical layers and insulator vertical layers. An easy axis of magnetization can be permanently or semi-permanently fixed in the ferromagnetic vertical layers along a first axis orthogonal to the core plane. A hard axis of magnetization can be permanently or semi-permanently induced in the ferromagnetic vertical layers, the hard axis of magnetization lying in a plane that is orthogonal to the first axis.

20180110123, Apr 19, 2018

Dec 15, 2017

15/844107

- New York NY, US
David Jew - New York NY, US
Joe Meyer - New York NY, US
Ryan Davies - New York NY, US
Hao Wu - New York NY, US
Michael Lekas - New York NY, US

H05K 1/18
H01F 41/04
H01F 41/02
H01F 27/28
H01F 27/24
H05K 1/16
H05K 1/02
H05K 1/11

A switched inductor DC-DC power converter chiplet includes a CMOS power switch, an LC filter, regulation circuitry, feedback control circuitry, and interface control circuitry integrated on a common substrate. The inductor for the LC filter can be formed on the same surface or on opposing surfaces of the substrate as the electrical terminations for the substrate.