Hao Q Liu

6593087, Jul 15, 2003

Dec 27, 2000

09/749340

Roger K. Prichard - Beaconsfield, CA
Ming Xu - Chino CA
Ana Paula Ribeiro - Montreal, CA
William J. Blackhall - Pointe Claire, CA
Robin N. Beech - Beaconsfield, CA
Marcelo Molento - Sainte-Anne-de-Bellevue, CA
Hao Yuan Liu - Newton MA

McGill University - Montreal

C12Q 168

435 6, 435 29, 435243, 435245, 514 30, 514 65, 514 89, 424405, 424422, 424424, 424426

This invention describes novel purified and isolated nucleic acid molecules or the fragments thereof, extracted from nematode or arthropod pests or recombinant, which encode P-glycoprotein homologs and regulate resistance to the macrocyclic lactone compounds. The invention further relates to the new P-glycoprotein homolog expression product of these nucleic acids. Also described herein are methods for detecting the gene encoding for resistance to the macrocyclic lactone compounds in nematode or arthropod pests which comprise comparing the nucleic acids extracted from a pest specimen to the nucleic acids encoding for resistance and the nucleic acids encoding for susceptibility to the macrocyclic lactone compounds. Lastly, the present invention is also drawn to methods and compositions for increasing the efficacy of the macrocyclic lactone compounds against resistant nematode or resistant arthropod pests which comprise administering to a mammal or applying to crops and the like a pesticidal enhancing effective amount of a multidrug resistance reversing agent.

7358053, Apr 15, 2008

Jun 6, 2003

10/456815

Roger K. Prichard - Beaconsfield, CA
Ming Xu - Chino CA, US
Ana Paula Ribeiro - Montreal, CA
William J. Blackhall - Pointe Claire, CA
Robin N. Beech - Beaconsfield, CA
Marcelo Molento - Sainte-Anne-de-Bellevue, CA
Hao Yuan Liu - Newton MA, US

McGill Univeristy - Montreal, Quebec

G01N 33/53

435 71, 436547

This invention describes novel purified and isolated nucleic acid molecules or the fragments thereof, extracted from nematode or arthropod pests or recombinant, which encode P-glycoprotein homologs and regulate resistance to the macrocyclic lactone compounds. The invention further relates to the new P-glycoprotein homolog expression product of these nucleic acids. Also described herein are methods for detecting the gene encoding for resistance to the macrocyclic lactone compounds in nematode or arthropod pests which comprise comparing the nucleic acids extracted from a pest specimen to the nucleic acids encoding for resistance and the nucleic acids encoding for susceptibility to the macrocyclic lactone compounds. Lastly, the present invention is also drawn to methods and compositions for increasing the efficacy of the macrocyclic lactone compounds against resistant nematode or resistant arthropod pests which comprise administering to a mammal or applying to crops and the like a pesticidal enhancing effective amount of a multidrug resistance reversing agent.

6403308, Jun 11, 2002

Apr 28, 1998

09/067676

Roger K. Prichard - Beaconsfield, CA
Ming Xu - Chino CA
Ana Paula Ribeiro - Montreal, CA
William J. Blackhall - Pointe Claire, CA
Robin N. Beech - Beaconsfield, CA
Marcelo Molento - Sainte-Anne-de-Bellevue, CA
Hao Yuan Liu - Newton MA

McGill University - Montreal

C12Q 168

435 6, 536 221

This invention describes novel purified and isolated nucleic acid molecules or the fragments thereof, extracted from nematode or arthropod pests or recombinant, which encode P-glycoprotein homologs and regulate resistance to the macrocyclic lactone compounds. The invention further relates to the new P-glycoprotein homolog expression product of these nucleic acids. Also described herein are methods for detecting the gene encoding for resistance to the macrocyclic lactone compounds in nematode or arthropod pests which comprise comparing the nucleic acids extracted from a pest specimen to the nucleic acids encoding for resistance and the nucleic acids encoding for susceptibility to the macrocyclic lactone compounds. Lastly, the present invention is also drawn to methods and compositions for increasing the efficacy of the macrocyclic lactone compounds against resistant nematode or resistant arthropod pests which comprise administering to a mammal or applying to crops and the like a pesticidal enhancing effective amount of a multidrug resistance reversing agent.

20210381819, Dec 9, 2021

Nov 6, 2019

17/287061

- Oakland CA, US
Chee Wei Wong - Los Angeles CA, US
Hao Liu - Los Angeles CA, US
Jinghui Yang - Los Angeles CA, US

The Regents of the University of California - Oakland CA

G01B 9/02
G02F 1/365
H01S 3/067
G01S 17/36
G01S 7/484

Systems and methods for soliton microcomb-based precision dimensional metrology via spectrally-resolved interferometry are described. In an embodiment, the system includes a dual-pumped soliton microcomb generator comprising a pump, a microresonator, and an auxiliary pump and that generates a single-soliton microcomb, an erbium-doped fiber amplifier that amplifies a C-band section of the soliton microcomb and a non-polarizing beam splitter that divides the soliton microcomb pulses into a reference arm pulse and a measurement arm pulse for an interferometer and recombines the reference arm pulse and the measurement arm pulse into a recombined beam upon their return.