US Patent:
20210356459, Nov 18, 2021
Inventors:
- Tarrytown NY, US
Saji Cherian - New City NY, US
Paul D'Agostino - Middletown NY, US
Gabriel Hammarquist - Halifax VT, US
Aili Han - Cypress CA, US
Kuldeep Jaggi - Mission Viejo CA, US
Maral Poladian - Encino CA, US
Niver Sahakian - Encino CA, US
Seema Sinha - Rancho Santa Margarita CA, US
Prakash Tewari - Carmel NY, US
Haekyung Lee - New York NY, US
Assignee:
Siemens Healthcare Diagnostics Inc. - Tarrytown NY
International Classification:
G01N 33/543
G01N 33/58
G01N 33/60
Abstract:
Disclosed herein are immunoassays for detecting an anti-thyroid peroxidase antibody in a biological sample from a subject and/or diagnosing a thyroid disease in a subject. The disclosed immunoassays employ a recombinant cynomolgus monkey thyroid peroxidase (rTPO) and assess the level of anti-thyroid peroxidase antibody-induced formation or disruption of complexes comprising a solid support and the rTPO.