Dean X Ho

20120135061, May 31, 2012

Jun 26, 2009

13/380520

Erik Pierstorff - Playa Del Rey CA, US
Edward Chow - San Francisco CA, US
Dean Ho - San Francisco CA, US
Christian Behrenbruch - Los Angeles CA, US

Cute Lovable Teddy Bear, LLC - Los Angeles CA

A61K 9/00

424422

This invention is in the field of controlled elution devices for therapeutic delivery. There exists a need for a stand-alone capable device for the localized and extended delivery of a therapeutic. This need is overcome by the present invention having an exemplary embodiment comprised of a microfilm base (), a reservoir of a therapeutic () disposed about the microfilm base () and a top layer () that is (i) a plurality of laminated layers () of para-xylyelne polymer and/or (ii) para-xylyelne polymer endowed with oxidatively functionalized para-xyele units. The thicknesses of the device is optimally in the range of about 10 to about 200 microns. The device is usable for the localized release of broad spectrum therapeutics for interventional and preventative medicine.

20170177834, Jun 22, 2017

Mar 23, 2015

15/127634

- Oakland CA, US
Dean HO - Los Angeles CA, US
Hann WANG - Los Angeles CA, US
Dong-Keun LEE - Los Angeles CA, US
Kai-Yu CHEN - Los Angeles CA, US

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

G06F 19/00
G01N 33/50
G06N 7/08

A cost function is specified to optimize a combination of N drugs, where the cost function includes at least one phenotypic contribution corresponding to efficacy and at least one phenotypic contribution corresponding to safety, and at least one of the N drugs is a nanomaterial-modified drug, with N being 2 or more. In vitro or in vivo tests are conducted by applying varying combinations of dosages of the N drugs to determine the phenotypic contributions from results of the tests. The results of the tests are fitted into a representation of the cost function, and, using the representation of the cost function, at least one optimized combination of dosages of the N drugs is identified.

20150238639, Aug 27, 2015

Feb 24, 2015

14/630289

- Singapore, SG
- Los Angeles CA, US
Dean HO - Los Angeles CA, US

A61K 49/10
A61K 49/08

A reagent comprising a nanodiamond particle linked to a paramagnetic ion for use as a contrast agent in magnetic resonance (MR) imaging in which T2-weighted magnetic images are obtained, and in particular in which both T1- and T2-weighted magnetic images are obtained, are described and claimed. Also claimed are novel reagents of this type, methods for their preparation and their use in diagnostics.

20140236080, Aug 21, 2014

Apr 24, 2014

14/260299

- Los Angeles CA, US
Christian Behrenbruch - Los Angeles CA, US
Edward Chow - San Francisco CA, US
Dean Ho - Chicago IL, US

CUTE LOVABLE TEDDY BEAR, LLC. - Los Angeles CA

A61K 47/32
A61L 15/44
A61L 15/24
A61K 9/70

604 9301

This invention is in the field of controlled elution devices for therapeutic delivery. There exists a need for a stand-alone capable device for the localized and extended delivery of a therapeutic. This need is overcome by the present invention having an examplary embodiment comprised of a microfilm base (), a reservoir of a therapeutic () disposed about the microfilm base () and a top layer () that is (i) a plurality of laminated layers () of para-xylyelne polymer and/or (ii) para-xylyelne polymer endowed with oxidatively functionalized para-xyele units. The thicknesses of the device is optimally in the range of about 10 to about 200 microns. The device is usable for the localized release of broad spectrum therapeutics for interventional and preventative medicine.