David P Liu

6340685, Jan 22, 2002

Mar 24, 1999

09/275176

Babu J. Mavunkel - Sunnyvale CA
John A. Lewicki - Los Gatos CA
David Y. Liu - Palo Alto CA
George F. Schreiner - Los Altos Hills CA
John J. Perumattam - Los Altos CA

Scios, Inc. - Sunnyvale CA

A61K 31496

514253, 544367, 544370, 544373

A compound of the formula: and the pharmaceutically acceptable salts thereof, wherein each of Z and Z is independently CR or N; where each R is independently H or is alkyl (1-6C) optionally including one or more heteroatoms selected from O, S and N and optionally substituted by one or more of halo, OR, SR, NR , RCO, COOR, CONR , OOCR, or NROCR where R is H or alkyl (1-6C), or by CN or O, or by an aliphatic or aromatic 5 or 6 membered ring optionally containing 1-2 N heteroatoms; or two R taken together form a bridge optionally containing a heteroatom; R is âwherein X is CO or an isostere thereof; m is 0 or 1; Y is optionally substituted alkyl, optionally substituted aryl, or optionally substituted arylalkyl or two 6 taken together may form an alkyene (2-3C) bridge; n is 0 or 2; Z is CH or N; X is CH, CH or an isostere thereof; and Ar consists of one or two phenyl moieties directly coupled to X optionally substituted by halo, nitro, alkyl (1-6C), alkenyl (1-6C), CN or CF , or by RCO, COOR, CONR , NR , OR, SR, OOCR or NROCR wherein R is H or alkyl (1-6C) or by phenyl, itself optionally substituted by the foregoing substituents; R is H, or alkyl (1-6C) optionally including one heteroatom which is O, S or N, and optionally substituted by one or more of halo, OR, SR, NR , RCO, COOR, CONR , OOCR, or NROCR where R is H or alkyl (1-6C), or by CN or O, or by an aliphatic or aromatic 5 or 6 membered ring optionally containing 1-2 N heteroatoms; R is H, halo, NO , alkyl (1-6C), alkenyl (1-6C), CN, OR, SR, NR , RCO, COOR, CONR , OOCR, or NROCR where R is H or alkyl (1-6C).

6391643, May 21, 2002

Oct 27, 1999

09/428587

Qiang Chen - Sunnyvale CA
David M. Liu - Los Altos CA
Brian S. Kersten - San Mateo CA
Christine M. Wu - Fremont CA

Cygnus, Inc. - Redwood City CA

G01N 3100

436 14, 436 8, 422 61, 435 14, 73 101, 73 102, 600347, 600365, 604 20

An automated system for continual transdermal extraction of analytes present in a biological system is described. The system optionally uses reverse iontophoresis to carry out the continual transdermal extraction of the analytes. The present invention describes quality control test kits, and methods of use thereof, for testing the ability of the system to provide reliable, effective, and accurate determination of analyte concentration.

6398562, Jun 4, 2002

Sep 17, 1999

09/398984

Michael J. Butler - San Francisco CA
Thomas E. Conn - Palo Alto CA
David M. Liu - Los Altos CA
Norman A. Parris - Belmont CA
Michael Reidy - Half Moon Bay CA
Pravin L. Soni - Sunnyvale CA

Cygnus, Inc. - Redwood City CA

H01R 458

439 91, 439909, 439725, 439596

Devices and methods are described for improving the contact of a conductive material, for example, a hydrogel, with a sensor, for example an electrode, by means of using mechanical force to apply the conductive material to the sensor before use of the conductive material and sensor in a sampling device. The device and methods of the present invention improve the sensor response characteristics in transdermal sampling devices placed in operative contact with a skin or mucosal surface of a biological system to obtain a chemical signal associated with an analyte of interest.

6448257, Sep 10, 2002

Mar 24, 2000

09/535316

Babu J. Mavunkel - Sunnyvale CA
David Y. Liu - Palo Alto CA
George F. Schreiner - Los Altos Hills CA
John A. Lewicki - Los Gatos CA

Scios, Inc. - Sunnyvale CA

A61K 31437

514292, 546 89

Compounds of the formula: wherein the dotted line represents an optional bond; and the pharmaceutically acceptable salts thereof, wherein X is an alkyl bridge optionally containing an O, S, or N heteroatom that forms an aliphatic 5-7 membered ring and is optionally substituted by one or more of halo, OR, SR, NR , RCO, COOR, CONR , OOCR, or NROCR where R is H or alkyl (1-6C), or by one or more CN or O, or by one or more aliphatic or aromatic 5- or 6-membered rings optionally containing 1-2 heteroatoms; R is âwherein X is CO or an isostere thereof; m is 0 or 1; Y is optionally substituted alkyl, optionally substituted aryl, or optionally substituted arylalkyl or two Y taken together may form an alkylene (2-3C) bridge; n is 0-4; Z is CH or N; X is CH or CHR where R is H or alkyl (1-6C), or an isostere thereof; and Ar, R and R are as defined in the specification. These compounds are selective inhibitors of p38 kinase.

6476031, Nov 5, 2002

Aug 27, 1999

09/383825

Sarvajit Chakravarty - Sunnyvale CA
Sundeep Dugar - Bridgewater NJ
John J. Perumattam - Los Altos CA
George F. Schreiner - Los Altos Hills CA
David Y. Liu - Palo Alto CA
John A. Lewicki - Los Gatos CA

Scios, Inc. - Sunnyvale CA

C07D23994

514249, 544293, 544258, 544279, 514259, 514258, 51425217

The invention is directed to methods to inhibit TGF- and/or p38- kinase using compounds of the formula or the pharmaceutically acceptable salts thereof wherein R is a noninterfering substituent; each Z is CR or N, wherein no more than two Z positions in ring A are N, and wherein two adjacent Z positions in ring A cannot be N; each R is independently a noninterfering substituent; L is a linker; n is 0 or 1; and Arâ is the residue of a cyclic aliphatic, cyclic heteroaliphatic, aromatic or heteroaromatic moiety optionally substituted with 1-3 noninterfering substituents.

6589954, Jul 8, 2003

May 21, 1999

09/316761

Babu J. Mavunkel - Sunnyvale CA
David Y. Liu - Palo Alto CA
George F. Schreiner - Los Altos Hills CA
John A. Lewicki - Los Gatos CA
John J. Perumattam - Los Altos CA

Scios, Inc. - Sunnyvale CA

A61K 31495

514253, 544367, 544373

Indoles, benzimidazoles and benztriazoles which are substituted at the 5 or 6 position with a substituent comprising an aromatic moiety linked through a piperazine ring to said indole, benzimidazole or benztriazole are useful in treating cardiac conditions associated with heart failure and in treating conditions characterized by proinflammation.

6596617, Jul 22, 2003

Jun 22, 2000

09/602658

David K.Y. Liu - Fremont CA

Progressant Technologies, Inc. - Fremont CA

H01L 2128

438606, 438141, 438237, 438 60, 438 52

A method of making an n-channel metal-insulator-semiconductor field-effect transistor (MISFET) that exhibits negative differential resistance in its output characteristic (drain current as a function of drain voltage) is disclosed. By implanting ions into a substrate that is later thermally oxidized, a number of temporary charge trapping sites can be established above a channel region of a transistor. The channel is also heavily doped, so that a strong electrical field can be generated to accelerate hot carriers into the temporary charge trapping sites. The insulating layer formed during the oxidation step is made sufficiently thick to prevent quantum tunnelingo of the hot carriers into a gate electrode. Other suitable and conventional processing steps are used to finalize completion of the fabrication of the NDR device so that the entire process is compatible and achieved with CMOS processing techniques.

6711063, Mar 23, 2004

Oct 3, 2002

10/264203

Anders T. Dejenfelt - Palo Alto CA
David Kuan-Yu Liu - Fremont CA

Xilinx, Inc. - San Jose CA

G11C 1606

36518521, 365 51, 365 63

An EEPROM memory cell array architecture ( ) that substantially eliminates leakage current to allow for reading memory cells ( ) in a memory cell array of, for example, a CPLD at lower voltages than are possible with prior art architectures, thereby facilitating development of low voltage applications. This is accomplished by associating each wordline of the memory cell array with a ground transistor ( ). On one embodiment, the ground transistor ( ) can be a high voltage transistor, in which case the same high voltage control signal can control both the ground transistor ( ) and the memory cell=s read transistor ( ). In another embodiment, the ground transistor ( ) is a low voltage transistor controlled by a separate low voltage control signal.