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Cindy Zer

from Whittier, CA
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Related to:
Rong Shen Shen, 55Jun Houn ZerPatricia Z Shen, 57Joe Zer, 56Joseph You Shen, 70
Connected to:
Anna M Zera, 83Barbara A Zera, 70Edward S Zera, 70Katarzyna Zera, 51Mark J Zera, 63Roy J Zera, 78Sally A Zera, 77Sandra Zera, 84Teresa A Zera, 62Jason M Zerafa, 58

Cindy Zer Phones & Addresses

  • Whittier, CA

Publications

Us Patents

Design And Development Of Masked Therapeutic Antibodies To Limit Off-Target Effects

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US Patent:
20130060010, Mar 7, 2013
Filed:
Mar 19, 2012
Appl. No.:
13/424272
Inventors:
John C. Williams - Monrovia CA, US
Cindy Zer - Whittier CA, US
Kendra N. Avery - Pasadena CA, US
International Classification:
C07K 19/00
US Classification:
5303873
Abstract:
In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a masked monoclonal antibody (mAb) is provided, which includes a therapeutic mAb and a mask, the mask comprising protein A and protein L attached by a protease cleavable linker.

Meditopes And Meditope-Binding Antibodies And Uses Thereof

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US Patent:
20120301400, Nov 29, 2012
Filed:
Apr 10, 2012
Appl. No.:
13/443804
Inventors:
John C. Williams - Monrovia CA, US
David A. Horne - Duarte CA, US
Yuelong Ma - Duarte CA, US
Heng Wei Chang - Foster City CA, US
Joshua Michael Donaldson - Lumberton NJ, US
Cindy Zer - Duarte CA, US
Krzysztof Bzymek - Pasadena CA, US
Kendra Nicole Avery - Pasadena CA, US
Jun Xie - Duarte CA, US
International Classification:
C07K 16/18
C07K 7/08
C07K 1/14
A61K 39/395
A61K 49/00
C12N 5/071
C07K 7/06
C07K 2/00
US Classification:
424 91, 5303879, 530330, 530329, 530328, 530327, 530326, 530321, 4241391, 4241781, 435331
Abstract:
Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.

Meditopes And Meditope-Binding Antibodies And Uses Thereof

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US Patent:
20230001003, Jan 5, 2023
Filed:
Dec 20, 2021
Appl. No.:
17/556863
Inventors:
- Duarte CA, US
David A. Horne - Duarte CA, US
Yuelong Ma - Duarte CA, US
Heng Wei Chang - Foster City CA, US
Joshua Michael Donaldson - Lumberton NJ, US
Cindy Zer - Duarte CA, US
Krzysztof Bzymek - Pasadena CA, US
Kendra Nicole Avery - Pasadena CA, US
Jun Xie - Duarte CA, US
International Classification:
A61K 47/68
C07K 16/28
C07K 16/32
B82Y 5/00
A61K 47/66
A61K 51/10
C07K 16/18
Abstract:
Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.

Design And Development Of Masked Therapeutic Antibodies To Limit Off-Target Effects

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US Patent:
20200164077, May 28, 2020
Filed:
Jul 2, 2019
Appl. No.:
16/460957
Inventors:
- Duarte CA, US
Cindy Zer - Duarte CA, US
Kendra N. Avery - Pasadena CA, US
Ulrich Rodeck - Philadelphia PA, US
Joshua M. Donaldson - Lumberion NJ, US
Csaba Kari - Rosemont CA, US
Assignee:
Thomas Jefferson University - Philadelphia PA
International Classification:
A61K 47/55
C07K 16/30
C07K 16/28
Abstract:
In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a masked monoclonal antibody (mAb) is provided, which includes a therapeutic mAb and a mask, the mask comprising protein A and protein L attached by a protease cleavable linker.

Meditopes And Meditope-Binding Antibodies And Uses Thereof

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US Patent:
20180193479, Jul 12, 2018
Filed:
Jun 5, 2017
Appl. No.:
15/614468
Inventors:
- Duarte CA, US
David A. Horne - Duarte CA, US
Yuelong Ma - Duarte CA, US
Heng Wei Chang - Foster City CA, US
Joshua Michael Donaldson - Lumberton NJ, US
Cindy Zer - Duarte CA, US
Krzysztof Bzymek - Pasadena CA, US
Kendra Nicole Avery - Pasadena CA, US
Jun Xie - Duarte CA, US
International Classification:
A61K 47/68
A61K 51/10
B82Y 5/00
C07K 16/18
C07K 16/28
C07K 16/32
Abstract:
Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.

Design And Development Of Masked Therapeutic Antibodies To Limit Off-Target Effects

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US Patent:
20160144042, May 26, 2016
Filed:
Nov 23, 2015
Appl. No.:
14/949648
Inventors:
- Duarte CA, US
Cindy ZER - Duarte CA, US
Kendra N. AVERY - Pasadena CA, US
International Classification:
A61K 47/48
Abstract:
In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a masked monoclonal antibody (mAb) is provided, which includes a therapeutic mAb and a mask, the mask comprising protein A and protein L attached by a protease cleavable linker.

Meditopes And Meditope-Binding Antibodies And Uses Thereof

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US Patent:
20150030535, Jan 29, 2015
Filed:
Aug 6, 2014
Appl. No.:
14/453586
Inventors:
- Duarte CA, US
David A. HORNE - Duarte CA, US
Yuelong MA - Duarte CA, US
Heng Wei CHANG - Foster City CA, US
Joshua M. DONALDSON - Lumberton NJ, US
Cindy ZER - Duarte CA, US
Krzysztof BZYMEK - Pasadena CA, US
Kendra N. AVERY - Pasadena CA, US
Jun XIE - Duarte CA, US
International Classification:
C07K 16/18
A61K 47/48
A61K 51/10
US Classification:
424 149, 4241331, 4241781, 5303873, 5303913, 5303917
Abstract:
Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.

Meditopes And Meditope-Binding Antibodies And Uses Thereof

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US Patent:
20140113348, Apr 24, 2014
Filed:
Feb 11, 2013
Appl. No.:
13/764762
Inventors:
- DUARTE CA, US
Cindy Zer - Duarte CA, US
Krzysztof Bzymek - Pasadena CA, US
Kendra Nicole Avery - Pasadena CA, US
Assignee:
City of Hope - Duarte CA
International Classification:
C07K 14/00
US Classification:
435188, 530317, 5303873
Abstract:
Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
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Cindy Zer from Whittier, CA Get Report