Cheng Dau Yu

7586008, Sep 8, 2009

Jul 9, 2008

12/170314

Chunlin Tao - Los Angeles CA, US
Cheng Zhi Yu - San Diego CA, US
Neil P. Desai - Los Angeles CA, US
Vuong Trieu - Calabasas CA, US

Abraxis Bioscience, Inc. - Los Angeles CA

C07C 49/00
C07C 325/00
C07F 9/02
A61K 31/12
A61K 31/125

568325, 568 20, 568 25, 568333, 568336, 558177, 514438, 514675, 514687, 514690

The invention provides para substituted dialkylphenol derivatives of propofol. The invention further provides pharmaceutical compositions comprising such analogs, methods for preparing such analogs, and methods of using such analogs to induce general anesthesia, sedation, and/or hypnotic or sleep effects in a patient.

7700612, Apr 20, 2010

Dec 23, 2004

10/583803

Patrick Soon-Shiong - Los Angeles CA, US
Neil P. Desai - Santa Monica CA, US
Chunlin Tao - Beverly Hills CA, US
Cheng Zhi Yu - San Diego CA, US

Abraxis BioScience, LLC - Los Angeles CA

A61K 31/4745
C07D 491/22

514283, 546 48

The present invention is related to 10,20-di-O ester derivatives of camptothecin and pharmaceutical formulations thereof. The compounds and pharmaceutical formulations of the present invention possess increased biological life span and bioavailability and reduced toxicity, while maintaining anti-cancer activity.

8026275, Sep 27, 2011

Feb 17, 2006

11/816311

Neil P. Desai - Los Angeles CA, US
Chunlin Tao - Los Angeles CA, US
Cheng Zhi Yu - San Diego CA, US
Vuong Trieu - Calabasas CA, US
Patrick Soon-Shiong - Los Angeles CA, US

Abraxis BioScience, LLC - Los Angeles CA

A01N 43/06
A01N 36/00
A61K 31/12
A61K 31/38

514438, 514675, 514687, 514690

The present invention provides novel 2,6-diisopropyl phenol2,6-diisopropyl phenol analogs and sterile, stable pharmaceutical compositions of 2,6-diisopropyl phenol 2,6-diisopropyl phenol and analogs thereof useful as an antioxidant in the treatment of ischemic injury including stroke and other cerebral injury. 2,6-diisopropyl phenol or its analogs are administered in a dosage effective to produce blood levels and brain levels of the drug that can prevent free radical damage associated with ischemic injury.

20070185217, Aug 9, 2007

Dec 23, 2004

10/584017

Chunlin Tao - Los Angeles CA, US
Cheng Yu - San Diego CA, US
Neil Desai - Santa Monica CA, US
Vuong Trieu - Calabasas CA, US

ABRAXIS BIOSCIENCE, INC. - LOS ANGELES CA

A61K 31/05

514730000, 568017000, 568300000, 568745000

The invention provides para substituted dialkylphenol derivatives of propofol. The invention further provides pharmaceutical compositions comprising such analogs, methods for preparing such analogs, and methods of using such analogs to induce general anesthesia, sedation, and/or hypnotic or sleep effects in a patient.

20090130163, May 21, 2009

Feb 21, 2006

11/816307

Neil P. Desai - Los Angeles CA, US
Chunlin Tao - Los Angeles CA, US
Cheng Zhi Yu - San Diego CA, US
Qinwei Wang - Arcadia CA, US
Patrick Soon-Shiong - Los Angeles CA, US

Abraxis Bio Scoence, Inc. - Los Angeles CA

A61F 2/04
A61K 31/337
A61K 31/4375
A61K 31/395
A61K 31/09
C07D 305/08
A61K 31/44
A61K 31/436
A61K 9/00

424423, 514449, 424400, 514283, 514291, 514183, 514355, 514719, 549510

The invention provides a medical device comprising a hydrophobic analog of a medicament known to inhibit cell proliferation and migration. The invention also provides a method of treating a narrowing in a body passageway comprising placing an implantable medical device comprising a hydrophobic analog of a medicament known to inhibit cell proliferation and migration. The medicaments can be incorporated within or coated on the device. The invention further provides hydrophobic analogs of medicaments known to inhibit cell proliferation and migration.

20100305148, Dec 2, 2010

Apr 13, 2010

12/759144

Patrick Soon-Shiong - Los Angeles CA, US
Neil P. Desai - Los Angeles CA, US
Chunlin Tao - Los Angeles CA, US
Cheng Zhi Yu - San Diego CA, US

Abraxis BioScience, LLC - Los Angeles CA

A61K 31/4375
C07D 491/22
A61P 35/02
A61P 35/00

514283, 546 48, 977773, 977906

The present invention is related to 10,20-di-O ester derivatives of camptothecin and pharmaceutical formulations thereof. The compounds and pharmaceutical formulations of the present invention possess increased biological life span and bioavailability and reduced toxicity, while maintaining anti-cancer activity.

20180318473, Nov 8, 2018

Jul 2, 2018

16/025671

- Los Angeles CA, US
Chunlin Tao - Newport Coast CA, US
Cheng Zhi Yu - San Diego CA, US
Qinwei Wang - Alhambra CA, US
Patrick Soon-Shiong - Los Angeles CA, US

A61L 31/16
A61K 31/395
A61L 31/14
A61K 31/145
A61K 31/337
A61L 29/08
A61L 31/10
A61L 27/34
A61L 29/16
A61L 27/54

The invention provides a medical device comprising a hydrophobic analog of a medicament known to inhibit cell proliferation and migration. The invention also provides a method of treating a narrowing in a body passageway comprising placing an implantable medical device comprising a hydrophobic analog of a medicament known to inhibit cell proliferation and migration. The medicaments can be incorporated within or coated on the device. The invention further provides hydrophobic analogs of medicaments known to inhibit cell proliferation and migration.

20170203012, Jul 20, 2017

Mar 31, 2017

15/476482

- Los Angeles CA, US
Chunlin Tao - Newport Coast CA, US
Cheng Zhi Yu - San Diego CA, US
Qinwei Wang - Alhambra CA, US
Patrick Soon-Shiong - Los Angeles CA, US

A61L 31/16
A61L 31/10
A61L 31/14
A61K 31/145

The invention provides a medical device comprising a hydrophobic analog of a medicament known to inhibit cell proliferation and migration. The invention also provides a method of treating a narrowing in a body passageway comprising placing an implantable medical device comprising a hydrophobic analog of a medicament known to inhibit cell proliferation and migration. The medicaments can be incorporated within or coated on the device. The invention further provides hydrophobic analogs of medicaments known to inhibit cell proliferation and migration.