Bong H Lee

6654915, Nov 25, 2003

Sep 11, 2000

09/658959

Scott Lu - Mission Viejo CA
Trent Lee England - Mission Viejo CA
Phen Cheng - Laguna Niguel CA
Bong Jae Lee - Laguna Niguel CA
Kathy Yishin Jaing - Irvine CA

Unisys Corporation - Blue Bell PA

G06F 1100

714 57, 714 43, 714 47

An automatic fault management system can monitor multiple platforms in a digital network to sense software and hardware malfunctions. An Event Log stores the details of each malfunction and enables an electronic service requester generator to develop formatted packets of information for transmittal to a remote service center. Administrative and monitor screens are made available to control and view each packet sent out and its status of receipt and return acknowledgment data.

6718489, Apr 6, 2004

Dec 7, 2000

09/731504

Bong Jae Lee - Laguna Niguel CA
Kathy Yishin Jaing - Irvine CA
Phen Cheng - Laguna Niguel CA
Scott Lu - Mission Viejo CA

Unisys Corporation - Blue Bell PA

G06F 1100

714 43, 714 47, 714 57

In an Automatic Fault Management System which monitors components on multiple platforms and workstations, an Electronic Service Generator operates to sense error events and selects an appropriate Formatter unit to develop a report packet for a Remote Service Unit.

8318795, Nov 27, 2012

Feb 29, 2008

12/528067

John S. Yu - Los Angeles CA, US
Bong Seop Lee - Torrance CA, US

Cedars-Sinai Medical Center - Los Angeles CA

A61K 31/385
C07D 339/04

514442, 549 38

The present invention describes polymers containing 1,2-dithiolanes capable of acting as scavengers of free radicals, metals and reactive oxygen species. Also described are methods of synthesizing the antioxidant 1,2-dithiolane derivatives and polymerization thereof to produce biodegradable antioxidant polymers. The antioxidant polymers of the present invention may be used to treat diseases or conditions caused by oxidative stress and other free radical mediated conditions. The antioxidant polymers may also be used for the preparation of antioxidant particulate delivery devices of therapeutic agents.

8603531, Dec 10, 2013

Apr 8, 2009

12/995125

John S. Yu - Los Angeles CA, US
Bong Seop Lee - Torrance CA, US

Cedars-Sinai Medical Center - Los Angeles CA

A61K 9/14
A61K 31/385
A61K 31/405
A61K 31/407
A61K 31/4436
C07D 409/12
C07D 339/04

424489, 514440, 514414, 514413, 514336, 5462807, 548493, 548516, 549 39

The present invention describes nanoprodrugs of non-steroidal anti-inflammatory drug (NSAIDs) and nanoprodrugs of α-lipoic acid-containing and NSAIDs. These nanoprodrugs have antioxidant properties and stimuli-responsiveness, which can be used to treat various disease conditions.

20100291222, Nov 18, 2010

Dec 30, 2008

12/811197

John S. Yu - Los Angeles CA, US
Bong Seop Lee - Torrance CA, US

CEDARS-SINAI MEDICAL CENTER - Los Angeles CA

A61K 9/14
C07D 409/12
C07D 409/14
A61K 31/497
A61K 31/385
A61K 31/4375
A61K 31/4188
A61K 38/02
A61K 31/7088

424489, 549 39, 544374, 51425213, 514440, 514283, 514393, 514 11, 514 44 R, 977773, 977906

The present invention is directed to multiple a-lipoic acid-containing hydrophobic compounds (mALAs) capable of acting as scavengers of free radicals, metals and reactive oxygen species (ROS). Methods of synthesizing novel antioxidant mALAs, spontaneous emulsification or nanoprecipitaion thereof to produce antioxidant nanospheres and their use in preventing or treating diseases or conditions caused by oxidative stress and other free radical mediated conditions are also described. Another aspect of this invention is the use of these antioxidant nanospheres for the preparation of antioxidant particulate delivery system of therapeutic agents.

20110300187, Dec 8, 2011

May 24, 2011

13/114539

John S. Yu - Los Angeles CA, US
Bong Seop Lee - Torrance CA, US

CEDAR- SINAI MEDICAL CENTER - Los Angeles CA

A61K 31/4745
A61K 9/14
A61P 35/00
C07D 491/22

424400, 546 48, 514283

The present invention is directed to antioxidant derivatives of camptothecin and antioxidant derivatives of camptothecin analogs and the preparation of nanometer-sized camptothecin prodrugs. Methods of synthesizing the antioxidant derivatives of camptothecin and antioxidant derivatives of camptothecin analogs, spontaneous emulsification or nanoprecipitation thereof to produce antioxidant camptothecin nanosphere prodrugs and their use in treating cancerous diseases are also provided. A further aspect of this invention is the use of these antioxidant camptothecin nanosphere prodrugs for the preparation of delivery devices of other pharmaceuticals and/or drugs. Additionally, methods of treating cancer with the camptothecin and antioxidant derivatives of camptothecin analogs, and nanometer-sized camptothecin prodrugs are also provided.

61286796, Oct 3, 2000

Feb 26, 1998

9/031138

Andrew Ward Beale - Aliso Viejo CA
Bong Jae Lee - Laguna Niguel CA
Dwayne Eugene Ebersole - Lancaster PA

Unisys Corporation - Blue Bell PA

G06F 1310

710 62

A computer for executing I/O instructions, by emulation, in a foreign application program includes an emulator program which has a Send thread, a Get thread, and single Result thread. The Send thread calls into a native operating system for the computer to send data from the foreign application program to an I/O port. The Get thread calls into the native operating system to receive data from the I/O port for the foreign application program. The Result thread processes one result descriptor from the native operating system when data is sent for the Send thread, and processes another result descriptor from the native operating system when data is received for the Get thread, and is completely blocked from running on the computer between the processing of the result descriptors. These threads are cleared, asynchronously with respect to the transfer of any data, by sending a CLEAR command from the emulator to the native operating system which responds by unblocking the Result thread and sending it a dummy result descriptor.

20160115192, Apr 28, 2016

Jun 10, 2014

14/895421

- Los Angeles CA, US
Bong Seop Lee - Torrance CA, US
Lei Zhang - Los Angeles CA, US

Cedars-Sinai Medical Center - Los Angeles CA

C07J 73/00
A61K 49/00
A61K 9/14

This invention relates to uses of conjugates of triptolide nanoprodrugs in cancer immunotherapy, specifically compound such as D-I or D-II wherein Xis a antioxidant, an anti-inflammatory or an anti-cancer agent and nanospheres thereof, and A is be selected from the group consisting of branched and unbranched alkyl, branched and unbranched alkenyl, branched and unbranched alkynyl, heteroatom-containing branched and unbranched alkyl, heteroatom-containing branched and unbranched alkenyl, heteroatom-containing branched and unbranched alkynyl, aryl, cyclic aliphatic, cyclic aromatic, heterocyclic, and aromatic heterocyclic groups.