Bin Chai Wang

6348449, Feb 19, 2002

Dec 16, 1994

08/357398

David B. Weiner - Merion PA
Bin Wang - Havertown PA
Kenneth E. Ugen - Philadelphia PA

The Trustees of the University of Pennsylvania - Philadelphia PA

A01N 4304

514 44, 4242091, 4241301, 4241841, 424325, 4352351, 4353201, 4352523, 4351723, 4352401, 4352402, 514 2, 514330

Methods of inducing mucosal immunity in individuals against proteins and peptides are disclosed. The methods comprise the step of administering topically or by lavage into mucosal tissue selected from the group consisting of rectal, vaginal, urethral, sublingual and buccal, a nucleic acid molecule that comprises a nucleotide sequence that encodes a protein or peptide that comprises an epitope against which mucosal immunity is desired. The methods may be used to immunize an individual against a pathogen infection, hyperproliferative diseases or autoimmune diseases using nucleic acid molecules which encode proteins and peptides that share an epitope with a pathogen antigen or protein associated with cells involved in hyperproliferative diseases or autoimmune diseases, respectively.

6468982, Oct 22, 2002

Jun 23, 1997

08/880576

David B. Weiner - Merion PA
William V. Williams - Havertown PA
Bin Wang - Havertown PA

The Trustees of the University of Pennsylvania - Philadelphia PA
The Wistar Institute - Philadelphia PA

A61K 4800

514 44, 4353201, 536 231, 514615, 514818

Methods of prophylactic and therapeutic immunization of an individual against pathogen infection, diseases associated with hyperproliferative cells and autoimmune diseases are disclosed. The methods comprise the steps of administering to cells of an individual, a nucleic acid molecule that comprises a nucleotide sequence that encodes a protein which comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen, a hyperproliferative cell associated protein or a protein associated with autoimmune disease respectively. In each case, nucleotide sequence is operably linked to regulatory sequences to enable expression in the cells. The nucleic acid molecule is free of viral particles and capable of being, expressed in said cells. The cells may be contacted cells with a cell stimulating agent. Methods of prophylactically and therapeutically immunizing an individual against HIV are disclosed.

7001759, Feb 21, 2006

Jul 23, 1999

09/359975

David B. Weiner - Merion PA, US
William V. Williams - Havertown PA, US
Bin Wang - Havertown PA, US

The Trustees of the University of Pennsylvania - Philadelphia PA
The Wistar Institute - Philadelphia PA

A61K 31/167
C12N 15/63
C12N 15/87
C07H 21/04

4353201, 536 231, 536 237, 536 2372, 514615, 514818, 514 44

Methods of introducing genetic material into cells of an individual and compositions and kits for practicing the same are disclosed. The methods comprise the steps of contacting cells of an individual with a polynucleotide function enhancer and administering to the cells, a nucleic acid molecule that is free of retroviral particles. The nucleic acid molecule comprises a nucleotide sequence that encodes a protein that comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen or an antigen associated with a hyperproliferative or autoimmune disease, a protein otherwise missing from the individual due to a missing, non-functional, or partially functioning gene, or a protein that produces a therapeutic effect on an individual. Methods of prophylactically and therapeutically immunizing an individual against pathogens are disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.

7220728, May 22, 2007

Feb 14, 2002

10/076900

David B. Weiner - Merion PA, US
Bin Wang - Havertown PA, US
Kenneth E. Ugen - Philadelphia PA, US

The Trustees of the University of Pennsylvania - Philadelphia PA

A61K 48/00
C12N 15/74

514 44, 4353201

Methods of inducing mucosal immunity in individuals against proteins and peptides are disclosed. The methods comprise the step of administering topically or by lavage into mucosal tissue selected from the group consisting of rectal, vaginal, urethral, sublingual and buccal, a nucleic acid molecule that comprises a nucleotide sequence that encodes a protein or peptide that comprises an epitope against which mucosal immunity is desired. The methods may be used to immunize and individual against a pathogen infection, hyperproliferative diseases or autoimmune diseases using nucleic acid molecules which encode proteins and peptides that share an epitope with a pathogen antigen or protein associated with cells involved in hyperproliferative diseases or autoimmune diseases, respectively,.

20130064841, Mar 14, 2013

Aug 31, 2012

13/601106

Richard Ascione - Jersey City NJ, US
Shengmei Qi - Jersey City NJ, US
Bin Wang - Jersey City NJ, US

C07K 14/435
C07K 7/06
A61P 37/04
A61K 39/00

4241851, 530324, 530329

Immunogens against human extended-progastrin species comprise (A) a mimetic peptide comprised of (i) the amino acid sequence of a progastrin or a N- and/or C-terminal processed species of a progastrin joined to (ii) a 7 amino-acid spacer coupled to (B) an immunogenic carrier. Illustrative of the mimetic peptide/spacer combination are a 21 amino-acid peptide (SEQ ID NO.: 1) and other, related polypeptides (SEQ ID NOs.: 2-5). Pharmaceutical compositions containing such an immunogen display improved immunological properties, including the induction of effective antibody levels shortly after the administration of an initial course of immunogen. Levels of antibody thus elicited stay elevated for several months and readily elevate to higher levels upon subsequent boosting by a single injection of immunogen.

58176373, Oct 6, 1998

Jan 13, 1997

8/783818

David B. Weiner - Merion PA
William V. Williams - Havertown PA
Bin Wang - Havertown PA

The Trustees of the University of Pennsylvania - Philadelphia PA
The Wistar Institute - Philadelphia PA

A61K 4505
A61K 4800
A61K 3100

514 44

Methods of prophylactic and therapeutic immunization of an individual against pathogen infection, diseases associated with hyperproliferative cells and autoimmune diseases are disclosed. The methods comprise the steps of administering to cells of an individual, a nucleic acid molecule that comprises a nucleotide sequence that encodes a protein which comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen, a hyperproliferative cell associated protein or a protein associated with autoimmune disease respectively. In each case, nucleotide sequence is operably linked to regulatory sequences to enable expression in the cells. The nucleic acid molecule is free of viral particles and capable of being expressed in said cells. The cells may be contacted cells with a cell stimulating agent. Methods of prophylactically and therapeutically immunizing an individual against HIV are disclosed.

55939724, Jan 14, 1997

Sep 21, 1993

8/125012

David B. Weiner - Merion PA
William V. Williams - Havertown PA
Bin Wang - Havertown PA

The Wistar Institute - Philadelphia PA
The Trustees of the University of Pennsylvania - Philadelphia PA

A61K 4505
A61K 4800
A61K 3100

514 44

Methods of prophylactic and therapeutic immunization of an individual against pathogen infection, diseases associated with hyperproliferative cells and autoimmune diseases are disclosed. The methods comprise the steps of administering to cells of an individual, a nucleic acid molecule that comprises a nucleotide sequence that encodes a protein which comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen, a hyperproliferative cell associated protein or a protein associated with autoimmune disease respectively. In each case, nucleotide sequence is operably linked to regulatory sequences to enable expression in the cells. The nucleic acid molecule is free of viral particles and capable of being expressed in said cells. The cells may be contacted cells with a cell stimulating agent. Methods of prophylactically and therapeutically immunizing an individual against HIV are disclosed.

58308768, Nov 3, 1998

May 30, 1995

8/453349

David B. Weiner - Merion PA
William V. Williams - Havertown PA
Bin Wang - Havertown PA

The Trustees of the University of Pennsylvania - Philadelphia PA
The Wistar Institute - Philadelphia PA

A61K 4505
A61K 4800
A61K 3100

514 44

A method of immunizing an individual against pathogen is disclosed. Also disclosed is a method of treating an individual who has a hyperproliferative disease, or of treating an individual who is infected by a pathogen. Specifically, the individual is injected with bupivacaine along with DNA in an expressible form, the DNA encoding an antigen. The encoded antigen can be from a protein from the pathogen or from a protein associated with the hyperproliferative disease.