Inventors:
Janssen Biotech, Inc. - Malvern PA, US
New York University - New York NY, US
Peter E. Daddona - Menlo Park CA, US
John Ghrayeb - Downingtown PA, US
David M. Knight - Berwyn PA, US
Scott A. Siegel - Ringoes NJ, US
Assignee:
NEW YORK UNIVERSITY - New York NY
JANSSEN BIOTECH, INC. - Malvern PA
International Classification:
A61K 39/395
Abstract:
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.