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Osborne Wong Phones & Addresses

  • 4913 Stoneback Pl, Laurence, KS 66047 (785) 843-6046
  • Lawrence, KS
  • Lenexa, KS
  • Ambler, PA
  • Foster City, CA
  • Redwood City, CA
  • 4913 Stoneback Pl, Laurence, KS 66047 (785) 766-0544

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Us Patents

Substituted 2,3-Naphthalenedicarboxaldehydes

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US Patent:
4723022, Feb 2, 1988
Filed:
Mar 10, 1986
Appl. No.:
6/837681
Inventors:
Richard S. Givens - Lawrence KS
Robert G. Carlson - Lawrence KS
Kasturi Srinivasachar - Rockville MD
Takeru Higuchi - Lawrence KS
Osborne S. Wong - Lenexa KS
Takeru Higuchi - Lawrence
Assignee:
Oread Laboratories, Inc. - Lawrence KS
International Classification:
C07D23502
C07C 6976
C07C 5976
C07C 8764
US Classification:
548326
Abstract:
A new class of substituted 2,3-naphthalenedicarboxaldehydes (NDA) is disclosed. Such compounds are of the formula: ##STR1## wherein one or more of R. sub. 1 -R. sub. 8 are various substituting groups. The above compounds react, in the presence of cyanide ion, with compounds containing primary amino groups to form adducts which exhibit a high fluorescent yield and thus are readily detected and measured by fluorometric assaying techniques.

Chemiluminescence Method For Assaying Compounds Containing Primary Amino Groups Using 1-Cyano-2-Substituted Benz(F)- Or Naphth(F)-Isoindole Fluorescers

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US Patent:
4758520, Jul 19, 1988
Filed:
Mar 10, 1986
Appl. No.:
6/837671
Inventors:
Bodgan Matuszewski - Lansdale PA
Richard S. Givens - Lawrence KS
Robert G. Carlson - Lawrence KS
Takeru Higuchi - Lawrence KS
Takao Kawasaki - Lawrence KS
Osborne S. Wong - Lenexa KS
Assignee:
Oread Laboratories, Inc. - Lawrence KS
International Classification:
G01N 2176
G01N 3352
G01N 3368
US Classification:
436 86
Abstract:
A chemiluminescence method for assaying compounds containing primary amino groups using 1-cyano-2-substituted benz(f)- or naphth(f)-isoindole fluorescers is disclosed. The 1-cyano-2-substituted benz(f)- or naphth(f)-isoindole (CBI or CNI) is formed by reacting a compound containing a primary amino group with naphthalene-2-3-dicarboxaldehyde or anthracene-2,3-dicarboxaldehyde in the presence of cyanide ion. The reaction product of hydrogen peroxide with an oxalate ester is then combined with the CBI or CNI to form an analyte which exhibits chemiluminescence. A detector is used to measure the chemiluminescence emission from the chemiluminescence derivatized analytes. Compounds containing primary amino groups which may be assayed according to the present invention include primary amines, amino acids, peptides and catecholamines. The method can also be adapted to the analysis of trace amounts of cyanide ion and hydrogen peroxide.
Osborne S Wong from Lawrence, KS, age ~65 Get Report