Lucia A. Santacruz Kozarinas - Chapel Hill NC,
Danny O. Jacobs - Durham NC,
DUKE UNIVERSITY - Durham NC
The present disclosure provides methods and compositions for detecting the presence and activity of creatine transporter proteins (CrT) in biological samples comprising screening the samples for CrT using antibodies that bind to the CrT. The methods are useful to detect the onset of cardiotoxicity in subjects undergoing treatment with anthrocyclines or those susceptible to heart-related conditions. The methods and compositions described herein in can be practiced with diagnostic kits.