Inventors:
Michael Marx - Sunnyvale CA
Lewis J. Throop - Los Altos CA
Assignee:
Syntex (U.S.A.) Inc. - Palo Alto CA
International Classification:
C07J 7100
A61K 3158
Abstract:
Novel, topically-active anti-inflammatory steroids are represented by the formula ##STR1## wherein X is fluoro, chloro or hydrogen; X. sup. 1 is fluoro, chloro, bromo, or hydrogen; X. sup. 2 is hydroxy or may be chloro when X. sup. 1 is chloro; and X. sup. 3 and X. sup. 4 are independently fluoro, chloro or bromo. These steroids are prepared by formylating at the 21-position a 16. alpha. ,17. beta. -isopropylidenedioxypregna-1,4,9(11)-triene-3,20-dione or the corresponding 21-fluoro compound, halogenating at the 21 position, deformylating, then reacting to add the desired components at the 9. alpha. and 11. beta. positions.