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Laurence G Rahme

from Brookline, MA
Age ~65
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Also known as:
Laurence L Rahme, Lawrence Rahme, Larry Rahme, Laurence Ranme, Rahme Laurence
Phone and address:
168 Winchester St, Brookline, MA 02446
(617) 734-6735
Connected to:
Wael Rahme, 52Mohammad A Rahmeh, 92Paul W Rahmeier, 91Gordon R Rahmes, 99Justin R Rahmes, 41Samantha J Rahmeyer, 32Lidya R Rahmi, 52Alexander L Rahmings, 54Jennifer E Rahming, 76Jeshua K Rahming, 37

Laurence Rahme Phones & Addresses

  • 168 Winchester St, Brookline, MA 02446 (617) 734-6735
  • 184 Winchester St, Brookline, MA 02446 (617) 713-4525 (617) 734-6735 (617) 383-5258
  • 49 Winchester St #184, Brookline, MA 02446 (617) 734-6735
  • 61 Pond St, Jamaica Plain, MA 02130 (617) 477-4077 (617) 734-6735
  • 9 Hawthorne St, Boston, MA 02114 (857) 991-1774
  • West Roxbury, MA
  • 100 South St #214 S, Sausalito, CA 94965 (415) 643-8945
  • Berkeley, CA
  • Newton Center, MA
  • Somerville, MA
  • 9 Hawthorne Pl APT 14D, Boston, MA 02114 (857) 991-1774

Resumes

Resumes

Laurence Rahme Photo 1

Professor Of Surgery, Microbiology And Immunobiology

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Location:
Portland, ME
Industry:
Research
Work:
Harvard Medical School
Professor of Surgery, Microbiology and Immunobiology
Harvard Medical School 1998 - Dec 2017
Associate Professor of Surgery, Microbiology and Immunobiology
American Society of Microbiology 1998 - Dec 2017
Elected Fellow - American Academy of Microbiology
Spero Therapeutics 1998 - Dec 2017
Scientific Founder
Massachusetts General Hospital 1998 - Dec 2017
Director of Molecular Surgical Laboratory
Education:
University of California, Berkeley 1987 - 1991
Doctorates, Doctor of Philosophy, Philosophy University of Naples, Italy 1980 - 1984
Bachelors
Skills:
Microbiology
Molecular Biology
Immunology
Cell
Laboratory
Life Sciences
Cell Biology
Research
Genetics
Infectious Diseases
Biotechnology
Bioinformatics
Cell Culture
Pcr
Molecular Genetics
Sequence Analysis
Lifesciences
Chemistry
Biochemistry
Transcriptomics
Medicine
Polymerase Chain Reaction
Laboratory Skills
Languages:
English
Italian
Greek
French
Laurence Rahme Photo 2

Laurence Rahme

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Publications

Us Patents

Methods Of Screening Compounds Useful For Prevention Of Infection Or Pathogenicity

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US Patent:
6461854, Oct 8, 2002
Filed:
Mar 28, 1995
Appl. No.:
08/411560
Inventors:
Frederick M. Ausubel - Newton MA
Laurence G. Rahme - Brookline MA
Man-Wah Tan - Somerville MA
Gary B. Ruvkun - Cambridge MA
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
A61K 4900
US Classification:
4352523, 424 91, 4242341, 435 4, 435 42, 435410, 435243, 43525234
Abstract:
Screening procedures are disclosed for identifying compounds useful for inhibiting infection or pathogenicity. Methods are also disclosed for identifying pathogenic virulence factors.

Methods Of Screening Compounds Useful For Prevention Of Infection Or Pathogenicity

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US Patent:
6905670, Jun 14, 2005
Filed:
May 22, 2002
Appl. No.:
10/153754
Inventors:
Frederick M. Ausubel - Newton MA, US
Stephen B. Calderwood - Wellesley MA, US
Eleftherios Mylonakis - Boston MA, US
Andrew Diener - Cambridge MA, US
Julia Plotnikova - Quincy MA, US
Costi D. Sifri - Quincy MA, US
Laurence G. Rahme - Brookline MA, US
Man-Wah Tan - Somerville MA, US
Gary B. Ruvkun - Newton MA, US
Georg Jander - Ithaca NY, US
Jacqueline Heard - San Mateo CA, US
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
A61K049/00
A01N063/00
A01N063/04
US Classification:
424 91, 424 931, 424 932, 424 935, 4242341, 435 4, 435 42, 435243, 4352541, 43525411, 435440, 536 231, 536 2324
Abstract:
Screening procedures are disclosed for identifying compounds useful for inhibiting fungal infection or pathogenicity. Methods are also disclosed for identifying fungal pathogenic virulence factors.

Methods Of Screening Compounds Useful For Prevention Of Infection Or Pathogenicity

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US Patent:
7166270, Jan 23, 2007
Filed:
Nov 3, 1997
Appl. No.:
08/962750
Inventors:
Frederick M. Ausubel - Newton MA, US
Laurence G. Rahme - Brookline MA, US
Man-Wah Tan - Somerville MA, US
Gary B. Ruvkun - Newton MA, US
Annegien Broeks - Amsterdam, NL
Ronald H. A. Plasterk - Bussam, NL
Georg Jander - Cambridge MA, US
Jacqueline Heard - San Ramon CA, US
Assignee:
The Netherlands Cancer Institute - Amsterdam
The General Hospital Corporation - Boston MA
International Classification:
A61K 49/00
A61K 35/00
A01N 63/00
US Classification:
424 92, 424 91, 424114, 424 9347, 4242601, 435874, 536 168
Abstract:
Screening procedures are disclosed for identifying compounds useful for inhibiting infection or pathogenicity. Methods are also disclosed for identifying pathogenic virulence factors.

Virulence-Associated Nucleic Acid Sequences And Uses Thereof

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US Patent:
20030022349, Jan 30, 2003
Filed:
Oct 10, 2001
Appl. No.:
09/975719
Inventors:
Frederick Ausubel - Newton MA, US
Laurence Rahme - Brookline MA, US
International Classification:
C12N009/50
C12P021/02
C12N001/21
C12N015/74
C07H021/04
US Classification:
435/219000, 435/069100, 435/252300, 435/320100, 536/023700
Abstract:
Disclosed are bacterial virulence polypeptides and nucleic acid sequences (e.g., DNA) encoding such polypeptides, and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial or bacteriostatic compounds.

Virulence-Associated Nucleic Acids And Proteins And Uses Thereof

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US Patent:
20050059018, Mar 17, 2005
Filed:
Sep 12, 2003
Appl. No.:
10/660811
Inventors:
Laurence Rahme - Brookline MA, US
Jianxin He - Malden MA, US
Regina Baldini - Sao Paulo, BR
Jens Solsbacher - Liederbach, DE
Peter Wagner - Idstein, DE
International Classification:
C12Q001/68
C07H021/04
C07K014/785
US Classification:
435006000, 435069100, 435320100, 435325000, 530350000, 536023500
Abstract:
The present invention features methods and compositions relating to bacterial virulence polypeptides and nucleic acid sequences (e.g., DNA) encoding such polypeptides. Based on the present invention, a pathogenic infection may be treated, prevented, or reduced by administering to an infected mammal or plant a therapeutically effective amount of a composition that inhibits the expression or activity of a polypeptide encoded by the virulence factors. Also disclosed are methods for producing such polypeptides by recombinant techniques as well as methods for utilizing such polypeptides to screen for antibacterial or bacteriostatic compounds.

Pseudomonas Virulence Factors And Uses Thereof

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US Patent:
20050089988, Apr 28, 2005
Filed:
Jan 3, 2003
Appl. No.:
10/497846
Inventors:
Stephen Calderwood - Wellesley MA, US
Ji Choi - Seon Gnam-Si, KR
Costi Sifri - Charlottesville VA, US
Laurence Rahme - Brookline MA, US
Frederic Ausubel - Newton MA, US
International Classification:
A61K039/02
C12N001/21
C12N015/74
US Classification:
435252340, 424200100, 530350000, 435069300, 435320100
Abstract:
Disclosed are bacterial virulence polypeptides and nucleic acid sequences (e.g., DNA) encoding such polypeptides, and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial or bacteriostatic compounds.

Methods For The Prevention Or Treament Of Bacterial And Fungal Infections

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US Patent:
20050119302, Jun 2, 2005
Filed:
Oct 30, 2002
Appl. No.:
10/493989
Inventors:
Laurence Rahme - Brookline MA, US
Hui Cao - Natick MA, US
Francois Lepine - Quebec Montreal, CA
Eric Deziel - Somerville MA, US
Ronald Tompkins - Boston MA, US
International Classification:
A61K031/47
US Classification:
514312000
Abstract:
The present invention features improved methods for treating, stabilizing, or preventing a bacterial or a fungal infection in a plant or an animal, such as a mammal. In particular, these methods involve the use of a compound, that is controlled by MvfR, and that affects the expression of an MvfR protein or that promotes its modification or inactivation, or a compound produced by strain PA14, but not by containing an mvfR mutation, in late stationary phase culture.

Virulence Associated Nucleic Acid Sequences And Uses Thereof

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US Patent:
20070105167, May 10, 2007
Filed:
Feb 3, 2006
Appl. No.:
11/275925
Inventors:
Frederick Ausubel - Newton MA, US
Laurence Rahme - Brookline MA, US
Assignee:
THE GENERAL HOSPITAL CORPORATION - Boston MA
International Classification:
G01N 33/554
C07K 14/195
US Classification:
435007320, 530350000
Abstract:
Disclosed are bacterial virulence polypeptides and nucleic acid sequences (e.g., DNA) encoding such polypeptides, and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial or bacteriostatic compounds.
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Laurence G Rahme from Brookline, MA, age ~65 Get Report