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John P Wikswo

from Brentwood, TN
Age ~75
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Also known as:
John Peter Wikswo, John Peter P
Phone and address:
1025 Manley Ln, Brentwood, TN 37027
(615) 373-0227
Related to:
Daniel Lammon, 76Salvatore Schillaci, 61Ronald Williams, 84Anthony VerderosaPatricia Williams, 84
Connected to:
Magdalena Wiktorko, 53Edward W Wiktorowicz, 66Andy Wil, 39Eric J Wilaby, 48Wade B Wilaby, 54John A Wilaj, 36Jennifer I Wilamo, 47Brenda S Wilamowski, 74Marlaina Wilamowski, 33Andrew S Wilan, 89

John Wikswo Phones & Addresses

  • 1025 Manley Ln, Brentwood, TN 37027 (615) 373-0227 (615) 243-9674
  • Santa Fe, NM

Work

Company: Vanderbilt university Sep 1977 Position: Professor

Education

Degree: Doctorates, Doctor of Philosophy School / High School: Stanford University 1970 to 1975 Specialities: Physics, Philosophy

Skills

Science • Research • Physics • Molecular Biology • Matlab • Nanotechnology • Mathematica • Life Sciences • Biomedical Engineering • Microscopy • Spectroscopy • Mathematical Modeling • Cell Culture • Data Analysis • Biochemistry • Biophysics • Materials Science • Microfluidics • Lifesciences • Statistics • Chemistry • Characterization • Superconductors

Languages

English

Industries

Nanotechnology

Resumes

Resumes

John Wikswo Photo 1

Professor

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Location:
1025 Manley Ln, Brentwood, TN 37027
Industry:
Nanotechnology
Work:
Vanderbilt University
Professor
Stanford University Oct 1975 - Aug 1977
Research Fellow In Cardiology
Dexmach 1975 - 1977
Vice President
Vanderbilt University 1975 - 1977
Gordon A Cain University Professor
Education:
Stanford University 1970 - 1975
Doctorates, Doctor of Philosophy, Physics, Philosophy University of Virginia 1966 - 1970
Bachelors, Bachelor of Arts, Physics Amherst County High School
Skills:
Science
Research
Physics
Molecular Biology
Matlab
Nanotechnology
Mathematica
Life Sciences
Biomedical Engineering
Microscopy
Spectroscopy
Mathematical Modeling
Cell Culture
Data Analysis
Biochemistry
Biophysics
Materials Science
Microfluidics
Lifesciences
Statistics
Chemistry
Characterization
Superconductors
Languages:
English

Publications

Us Patents

Capillary Perfused Bioreactors With Multiple Chambers

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US Patent:
7534601, May 19, 2009
Filed:
Aug 27, 2003
Appl. No.:
10/525559
Inventors:
John P. Wikswo - Brentwood TN, US
Franz J. Baudenbacher - Franklin TN, US
Alex Prokop - Nashville TN, US
Eugene J. Leboeuf - Franklin TN, US
Chang Y. Chung - Franklin TN, US
David Cliffel - Nashville TN, US
Frederick R. Haselton - Nashville TN, US
William H. Hofmeister - Nashville TN, US
Charles P. Lin - Brentwood TN, US
Lisa J. McCawley - Nashville TN, US
Randall S. Reiserer - Nashville TN, US
Mark A. Stremler - Franklin TN, US
Assignee:
Vanderbilt University - Nashville TN
International Classification:
C12M 1/00
US Classification:
4352891
Abstract:
A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel.

Apparatus And Methods For Monitoring The Status Of A Metabolically Active Cell

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US Patent:
7704745, Apr 27, 2010
Filed:
Aug 6, 2002
Appl. No.:
10/213049
Inventors:
Franz Baudenbacher - Franklin TN, US
John P. Wikswo - Brentwood TN, US
R. Robert Balcarcel - Nashville TN, US
David Cliffel - Nashville TN, US
Sven Eklund - Antioch TN, US
Jonathan Mark Gilligan - Nashville TN, US
Owen McGuinness - Brentwood TN, US
Todd Monroe - Baton Rouge LA, US
Ales Prokop - Nashville TN, US
Mark Andrew Stremler - Franklin TN, US
Andreas Augustinus Werdich - Nashville TN, US
Assignee:
Vanderbilt University - Nashville TN
International Classification:
G01N 33/00
US Classification:
436 34, 435 11, 435 2, 435 3, 435 29, 435366, 435373, 435374, 4352852, 4352861, 4352871, 436 2, 436 50, 436 62, 436 63, 436 68, 436147, 436149, 422 8201, 422 90, 422 91, 422 92
Abstract:
An apparatus and methods for monitoring the status of a cell that consumes oxygen. In one embodiment of the present invention, the method includes the steps of confining the cell in a sensing volume, measuring dynamically intracellular or extracellular signaling of the cell, and determining the status of the cell from the measured intracellular or extracellular signaling of the cell.

Device And Methods For Detecting The Response Of A Plurality Of Cells To At Least One Analyte Of Interest

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US Patent:
7713733, May 11, 2010
Filed:
Aug 6, 2002
Appl. No.:
10/483466
Inventors:
David Cliffel - Nashville TN, US
Franz J. Baudenbacher - Franklin TN, US
John P. Wikswo - Brentwood TN, US
Sven Eklund - Antioch TN, US
R. Robert Balcarcel - Nashville TN, US
Jonathan M. Gilligan - Nashville TN, US
Assignee:
Vanderbilt University - Nashville TN
International Classification:
C12M 1/22
C12M 3/00
C12M 1/34
US Classification:
4353051, 4353052, 4352885, 4352883, 4352884, 435244, 435 30, 4353053, 2057775, 205778, 205779
Abstract:
An apparatus and methods for detecting at least one analyte of interest either produced or consumed by a plurality of cell. In one embodiment of the present invention, the method includes the steps of providing a housing defining a chamber, placing a plurality of cells in the chamber, and simultaneously detecting at least two analytes of interest either produced or consumed by the plurality of cells in the chamber.

Bioreactors With Substance Injection Capacity

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US Patent:
7790443, Sep 7, 2010
Filed:
Aug 27, 2003
Appl. No.:
10/525648
Inventors:
John P. Wikswo - Brentwood TN, US
Franz J. Baudenbacher - Franklin TN, US
Frederick R. Haselton - Nashville TN, US
William H. Hofmeister - Nashville TN, US
Charles P. Lin - Brentwood TN, US
Lisa J. McCawley - Nashville TN, US
Mark A. Stremler - Franklin TN, US
Alissa Weaver - Nashville TN, US
Assignee:
Vanderbilt University - Nashville TN
International Classification:
C12M 1/00
C12M 3/00
US Classification:
4352891, 4352931, 4352972
Abstract:
A bioreactor with substance injection capability. In one embodiment, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a chamber for receiving cells and a liquid medium. A port is formed in the second substrate between the bottom surface and the first surface of the second substrate. As formed, the port is in fluid communication with the chamber to allow a stream of substance to be introduced into the chamber. The stream of substance is controlled so as to provide a gradient, or a concentration gradient of the substance, to the chamber.

Bioreactors With Multiple Chambers

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US Patent:
7977089, Jul 12, 2011
Filed:
Aug 27, 2003
Appl. No.:
10/525549
Inventors:
John P. Wikswo - Brentwood TN, US
Franz J. Baudenbacher - Franklin TN, US
David Cliffel - Nashville TN, US
Frederick R. Haselton - Nashville TN, US
Eugene J. Leboeuf - Franklin TN, US
Ales Prokop - Franklin TN, US
Randall S. Reiserer - Nashville TN, US
Mark A. Stremler - Franklin TN, US
Assignee:
Vanderbilt University - Nashville TN
International Classification:
C12M 1/22
C12M 3/00
C12M 1/34
US Classification:
4353052, 4352887, 435808, 4352884, 4352885, 4352971, 4353051, 4352975, 2057775, 205778, 205779, 20440301
Abstract:
A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor has a first substrate having a first surface and an opposite second surface, defining a chamber therebetween for receiving the cells and the liquid medium. The bioreactor further has a barrier dividing the chamber into a first subchamber and a second subchamber, wherein the barrier has a porosity to allow the first subchamber and the second subchamber in fluid communication and allow at least one predetermined type of cells to permeate between the first subchamber and the second subchamber.

Device And Methods For Monitoring The Status Of At Least One Cell

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US Patent:
7981649, Jul 19, 2011
Filed:
Aug 22, 2008
Appl. No.:
12/229503
Inventors:
John P. Wikswo - Brentwood TN, US
Franz J. Baudenbacher - Franklin TN, US
Owen McGuiness - Brentwood TN, US
Assignee:
Vanderbilt University - Nashville TN
International Classification:
C12N 13/00
C12M 1/34
C12M 3/00
US Classification:
4351735, 4352883, 4353053, 4352884, 435244, 4351734, 4352852, 4352882, 4352885, 4351737, 435 30, 20440301
Abstract:
A device and methods for monitoring status of at least one cell, wherein the cell has a membrane forming a substantially enclosed structure and defining an intracellular space therein. In one embodiment of the present invention, the device includes a first substrate having a first surface and an opposite second surface, a second substrate supported by the first substrate, the second substrate having a first surface, an opposite second surface, a body portion between the first surface and the second surface, a first side surface and an opposite second side surface, wherein the body portion defines a first passage between the first side surface and the second side surface and an opening on the first surface of the second substrate and in fluid communication with the first passage, and sidewalls positioned above the first surface of the second substrate. In one operation mode, when a first medium is introduced into the first passage, the intracellular space of the cell is in fluid communication with the first passage with the first medium, a sensor measures the response of the cell to the first medium.

Capillary Perfused Bioreactors With Multiple Chambers

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US Patent:
8003378, Aug 23, 2011
Filed:
Mar 5, 2009
Appl. No.:
12/398825
Inventors:
John P. Wikswo - Brentwood TN, US
Franz J. Baudenbacher - Franklin TN, US
Ales Prokop - Nashville TN, US
Eugene LeBoeuf - Franklin TN, US
Chang Y. Chung - Franklin TN, US
David E. Cliffel - Nashville TN, US
Frederick R. Haselton - Nashville TN, US
William H. Hofmeister - Nashville TN, US
Charles P. Lin - Brentwood TN, US
Lisa J. McCawley - Nashville TN, US
Randall S. Reiserer - Nashville TN, US
Mark A. Stremler - Franklin TN, US
Assignee:
Vanderbilt University - Nashville TN
International Classification:
C12M 1/00
US Classification:
4352891
Abstract:
A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel.

Bioreactors With An Array Of Chambers And A Common Feed Line

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US Patent:
8129179, Mar 6, 2012
Filed:
Aug 27, 2003
Appl. No.:
10/525538
Inventors:
John F. Wikswo - Brentwood TN, US
David Cliffel - Nashville TN, US
Eugene J. Leboeuf - Franklin TN, US
Randall S. Reiserer - Nashville TN, US
Assignee:
Vanderbilt University - Nashville TN
International Classification:
C12M 1/00
C12M 3/00
C12M 1/34
C12M 1/22
US Classification:
4353052, 4352883, 4352884, 4352885, 4352891, 4352975, 4353051, 4352873
Abstract:
A bioreactor () for cultivating living cells in a liquid medium. In one embodiment, the bioreactor () has a substrate () having a first surface and an opposite second surface, defining a channel () therein, and a plurality of chambers () formed in the substrate, wherein each of the plurality of chambers () is adapted for receiving cells in a liquid medium and formed with an open end (), an opposite closed end () and side walls, the open end () and the closed end () defining a depth, d, therebetween for the corresponding chamber (), the sidewalls defining a width, w, therebetween for the corresponding chamber (). As such formed, each chamber () is in fluid communication with the channel () through the open end of the chamber (), and at least two of the plurality of chambers () have depths or widths the same or different form each other.

Wikipedia

John Wikswo

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John Peter Wikswo, Jr. (born October 6, 1949) is a biological physicist at Vanderbilt University. He was born in Lynchburg, Virginia, United States. ...
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John P Wikswo from Brentwood, TN, age ~75 Get Report