Takushi Kaneko - Guilford CT
Henry S. Wong - Durham CT
Jacob J. Utzig - Buffalo NY
Bristol-Myers Company - New York NY
There are disclosed analogs of the antitumor agent, rebaccamycin, which possess antineoplastic properties against mammalian, particularly experimental animal, tumor systems. The compounds of the invention are aminoalkylated derivatives of rebeccamycin produced by first reacting rebeccamycin with a strong base to obtain a reactive intermediate and then reacting the reactive intermediate with an aminoalkyl compound.