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Daniela Mottel Witten

from Seattle, WA
Age ~41
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Also known as:
Daniela M Witten
Phone and address:
9510 Lake Shore Blvd NE, Seattle, WA 98115
(206) 522-6305
Related to:
Stefanie Witten, 23Edward Witten, 73Chiara Nappi, 77Ilana Witten, 45Benjamin T Ridley, 38Rafael Witten, 34
Connected to:
Adrian Wittenberg, 39Allie N Witten, 41Andrew C Witten, 38Ariel R Wittenberg, 35Batya Wittenberg, 49Benjamin O Wittenberg, 42Bonnie L Wittenburg, 73Brian W Wittenberg, 49Brooke K Wittenburg, 52Caleb A Wittenburg, 37

Daniela Witten Phones & Addresses

  • 9510 Lake Shore Blvd NE, Seattle, WA 98115 (206) 522-6305
  • Menlo Park, CA
  • Stanford, CA
  • Princeton, NJ

Work

Company: University of washington Sep 2018 Position: Professor

Education

Degree: Doctorates, Doctor of Philosophy School / High School: Stanford University 2006 to 2010 Specialities: Statistics, Philosophy

Industries

Research

Resumes

Resumes

Daniela Witten Photo 1

Professor

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Location:
Seattle, WA
Industry:
Research
Work:
University of Washington
Professor
University of Washington Jul 2014 - Sep 2018
Associate Professor
University of Washington Sep 2010 - Jul 2014
Assistant Professor
Education:
Stanford University 2006 - 2010
Doctorates, Doctor of Philosophy, Statistics, Philosophy Stanford University 2005 - 2006
Master of Science, Masters, Statistics Stanford University 2001 - 2005
Bachelors, Bachelor of Science, Mathematics

Publications

Us Patents

Viral Inhibitory Nucleotide Sequences And Vaccines

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US Patent:
20100203081, Aug 12, 2010
Filed:
Jul 12, 2007
Appl. No.:
12/373605
Inventors:
Raul Rabadan - Princeton NJ, US
Michael Krasnitz - Princeton NJ, US
Harlan Robins - Seattle WA, US
Daniela Witten - Princeton NJ, US
Arnold Levine - Doylestown PA, US
Assignee:
INSTITUTE FOR ADVANCED STUDY - Princeton NJ
International Classification:
A61K 39/12
C07H 21/00
C07K 14/00
C12N 7/01
C12N 5/10
A61P 31/12
A61P 37/04
US Classification:
4242041, 536 2372, 530350, 4352351, 435348
Abstract:
The invention relates to inhibitory nucleotide signal sequences or “INS” sequences in the genomes of lentiviruses. In particular the invention relates to the AGG motif present in all viral genomes. The AGG motif may have an inhibitory effect on a virus, for example by reducing the levels of, or maintaining low steady-state levels of, viral RNAs in host cells, and inducing and/or maintaining in viral latency. In one aspect, the invention provides vaccines that contain, or are produced from, viral nucleic acids in which the AGG sequences have been mutated. In another aspect, the invention provides methods and compositions for affecting the function of the AGG motif, and methods for identifying other INS sequences in viral genomes.

Viral Inhibitory Nucleotide Sequences And Vaccines

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US Patent:
20170073376, Mar 16, 2017
Filed:
Aug 4, 2016
Appl. No.:
15/228451
Inventors:
- Princeton NJ, US
Michael KRASNITZ - Princeton NJ, US
Harlan ROBINS - Seattle WA, US
Daniela WITTEN - Princeton NJ, US
Arnold LEVINE - Doylestown PA, US
International Classification:
C07K 14/005
A61K 39/21
Abstract:
The invention relates to inhibitory nucleotide signal sequences or “INS” sequences in the genomes of lentiviruses. In particular the invention relates to the AGG motif present in all viral genomes. The AGG motif may have an inhibitory effect on a virus, for example by reducing the levels of, or maintaining low steady-state levels of, viral RNAs in host cells, and inducing and/or maintaining in viral latency. In one aspect, the invention provides vaccines that contain, or are produced from, viral nucleic acids in which the AGG sequences have been mutated. In another aspect, the invention provides methods and compositions for affecting the function of the AGG motif, and methods for identifying other INS sequences in viral genomes.

A Framework For Determining The Relative Effect Of Genetic Variants

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US Patent:
20160357903, Dec 8, 2016
Filed:
Sep 20, 2014
Appl. No.:
15/023355
Inventors:
- Seattle WA, US
- Huntsville AL, US
Martin Kircher - Seattle WA, US
Daniela Witten - Seattle WA, US
Assignee:
University of Washington through its Center for Commercialization - Seattle WA
Hudsonsalpha Institute for Biotechnology - Huntsville AL
International Classification:
G06F 19/22
G06F 19/24
Abstract:
Current methods for annotating and interpreting human genetic variation typically exploit only a single information type (e.g., conservation) and/or are restricted in scope (e.g., to missense changes). Here, a method for objectively integrating many diverse annotations into a single measure (integrated deleteriousness score, or C-score) for each variant is described. The method may be implemented as a support vector machine (SVM) trained to differentiate high-frequency human-derived alleles from simulated variants. C-scores were precomputed for all 8.6 billion possible human single-nucleotide variants and allow scoring of short insertions-deletions. C-scores correlate with allelic diversity, annotations of functionality, pathogenicity, disease severity, experimentally measured regulatory effects and complex trait associations, and they highly rank known pathogenic variants within individual genomes. The ability of CADD to prioritize functional, deleterious and pathogenic variants across many functional categories, effect sizes and genetic architectures is unmatched by any current single-annotation method.
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Daniela Mottel Witten from Seattle, WA, age ~41 Get Report